The San Diego Padres (36-26) visit the Milwaukee Brewers (34-30) for the second game of their 3-game series on Saturday. First pitch from American Family Field is at 7:35 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s MLB odds around the Padres vs. Brewers odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 1-0

The Padres have won 4 of their last 6 games and 8 of their last 12. They snapped a small 2-game skid by winning Friday’s opener in Milwaukee 2-0. 3B Manny Machado hit his ninth homer of the season and 5 pitchers combined for the shutout — yielding just 4 hits — with RP Robert Suarez picking up his 20th save. The Padres were +131 underdogs and the Under (8.5) easily cashed.

The Brewers have been red-hot, going 9-2 in their last 11 games, although they have lost 2 of their last 3 outings. They left 10 on base in Friday’s loss, going 1-for-9 with runners in scoring position — the hit was an infield single that moved a runner from second to third. Four of the top 5 batters in the lineup each had 1 hit, but that was it. SP Chad Patrick (3-5) took the loss but pitched well — 6 IP, 1 ER, 4 H, 3 BB, 6 K.

Padres at Brewers projected starters

RHP Stephen Kolek vs. LHP Jose Quintana

Kolek (3-1, 3.47 ERA) makes his seventh start. He has a 1.24 WHIP, 3.0 BB/9 and 6.7 K/9 through 36 1/3 innings.

Last start: No-decision, 5 2/3 IP, 0 ER, 3 H, 2 BB, 3 K in 1-0, 10-inning win at San Francisco Giants MondayCareer vs. Brewers: 1-0, 0.00 ERA (3 IP, 0 ER), 2.00 WHIP, 4 H, 2 BB, 2 K in 2 relief appearancesDidn’t allow a run in 3 of his 6 starts, including in 3 of his 4 road outings2025 road splits: 2-0, 1.04 ERA (26 IP, 3 ER), 1.08 WHIP, 6.9 K/9 in 4 starts

Quintana (4-1, 2.77 ERA) makes his eighth start. He has a 1.28 WHIP, 3.5 BB/9 and 6.2 K/9 through 39 innings.

Last start: No-decision, 5 IP, 2 ER, 4 H, 4 BB. 3 K in 5-2 win at Philadelphia Phillies SundayAllowed 2 or fewer runs in 6 of 7 starts this seasonCareer vs. Padres: 3-0, 4.25 ERA (42 1/3 IP, 20 ER), 1.28 WHIP, 6.6 K/9 in 9 outings (7 starts)2025 home splits: 1-1, 5.91 ERA (10 2/3 IP, 7 ER), 1.41 WHIP, 11 H, 4 BB, 10 K in 2 starts

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Padres at Brewers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 2:41 p.m. ET.

Moneyline (ML): Padres +100 (bet $100 to win $100) | Brewers -120 (bet $120 to win $100)Run line (RL)/Against the spread (ATS): Padres -1.5 (+155) | Brewers +1.5 (-190)Over/Under (O/U): 8.5 (O: -105 | U: -115)Padres at Brewers picks and predictionsPrediction

Padres 4, Brewers 2

The Padres are 16-16 on the road this season but 4-2 in their last 6 games away from home. The Brewers are 18-11 at home, but Quintana has not been as good in his 2 home starts as Kolek has been on the road this season.

Dating back to last season, the Padres have won 4 of the last 5 meetings against the Brewers.

BET PADRES (+100).

The Padres have 5 1-run wins in their last 9 victories, while 7 of the Brewers’ last 9 losses have been by multiple runs.

The ML is a solid bet on its own but you can have some additional potential winnings by laddering that bet with one smaller one on the Padres to cover. They are 17-15 ATS on the road, per Teamrankings.com

BET PADRES -1.5 (+155).

Just don’t wager more than 1½ total units between the 2 bets above (ML & RL).

Quintana’s last 4 starts and 6 of 7 have not surpassed 8 total runs.

Four of the Padres’ last 5 wins and 6 of their last 8 games overall have had totals of 8 or fewer runs.

BET UNDER 8.5 (-115).

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