The Cincinnati Reds (34-33) and Cleveland Guardians (34-31) play the second game of their 3-game series Tuesday. First pitch from Progressive Field in Cleveland is set for 6:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Reds vs. Guardians odds and make our expert MLB picks and predictions for the best bets.

Season series: Reds lead 4-0

The Reds earned a 7-4 win over the Guardians on Monday night, cashing as +133 road underdogs while the Over (9) hit. OF Jake Fraley led the way, going 3-for-4 with a home run, 2 RBIs, and a stolen base. OF TJ Friedl added a solo shot and scored twice. It marked Cincinnati’s fourth straight victory.

The Guardians lost their fourth game in the last 5 outings. SP Luis Ortiz (4 2/3 IP, 4 ER, 9 H) took the loss to fall to 3-7. C Bo Naylor went 2-for-3 with a homer. Cleveland has been outscored 19-10 by Cincinnati this season.

Reds at Guardians projected starters

LHP Andrew Abbott vs. RHP Slade Cecconi

Abbott (5-1, 2.18 ERA) is making his 11th start. He has a 1.06 WHIP, 3.2 BB/9 and 9.9 K/9 through 53 2/3 innings.

Last start: Loss, 6 IP, 5 ER, 7 H (2 HR), 1 BB, 6 K in 9-1 home loss against the Milwaukee Brewers Wednesday2025 road stats: 2-0, 2.05 ERA (22 IP, 5 ER), 0.86 WHIP, 12.7 K/9 in 4 startsCareer vs. Guardians: 2-1, 3.65 ERA (12 1/3 IP, 5 ER), 1.70 WHIP, 8.0 K/9 in 3 startsLast start vs. Guardians: Win, 5 IP, 0 ER, 4 H, 3 BB, 5 K in 3-1 home victory May 18

Cecconi (1-2, 4.87 ERA) is making his fifth start. He has a 1.43 WHIP, 3.1 BB/9 and 8.9 K/9 through 20 1/3 innings.

Last start: Loss, 5 IP, 2 ER, 5 H, 2 BB, 3 K in 4-0 defeat at New York Yankees ThursdayOnly home start: No-decision, 4 1/3 IP, 5 ER, 7 H, 3 BB, 3 K in 7-5 against the Los Angeles Angels May 31Career vs. Reds: 0-2, 4.57 ERA (21 1/3 IP, 11 ER), 1.02 WHIP, 7.5 K/9 in 4 startsLast start vs. Reds: Loss, 5 IP, 3 ER, 5 H, 0 BB, 8 K in 4-1 road defeat May 17

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Reds at Guardians odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:23 a.m. ET.

Moneyline (ML): Reds -105 (bet $105 to win $100) | Guardians -115 (bet $115 to win $100)Run line (RL)/Against the spread (ATS): Reds -1.5 (+165) | Guardians +1.5 (-200)Over/Under (O/U): 8 (O: -110 | U: -110)Reds at Guardians picks and predictionsPrediction

Reds 3, Guardians 1

BET REDS (-105).

The Reds are red-hot heading into Tuesday’s matchup, riding a 4-game win streak while outscoring opponents 28-10 during that stretch. They’ve completely controlled the season series against the Guardians, winning all 4 matchups so far.

Cincinnati hands the ball to Abbott, who’s been a model of consistency this year. The left-hander has held opponents to 1 earned run or fewer in 8 of his 10 starts. That spells trouble for a Cleveland lineup that has struggled against lefties all season, hitting just .224 as a team. Abbott already shut them down earlier this year, tossing 5 scoreless innings.

With Cincinnati’s bats rolling and Abbott in command, the Reds offer strong value. This is a great spot to back them again.

PASS.

No need to play with the run line when you are getting the Reds at almost plus money on the moneyline.

BET UNDER 8 (-110).

The trends point strongly toward the Under in Tuesday’s matchup between the Reds and Guardians.

The Under has hit in 8 of the last 10 meetings. Cleveland has gone Under in 7 of its last 10 games, while Cincinnati has hit the Under in 6 of its last 10 contests. Abbott has stayed Under in 4 of his last 6 starts, and Cecconi is 3-1 to the Under this season.

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