The Chicago White Sox (23-44) and Houston Astros (36-30) will meet on Wednesday at Daikin Park, with first pitch at 8:10 p.m. ET.
The White Sox (+150 underdog moneyline odds) are away versus the Astros (-181). The Houston Astros will hand the ball to Ryan Gusto (3-3, 4.78 ERA), who is looking for win No. 4 on the season, and the White Sox will counter with Sean Burke (3-6, 4.03 ERA).
Yesterday, the White Sox picked up a 4-2 win over the Astros, with Shane Smith (6.0 IP, 1 R, 7 H, 4 K) earning the win for the White Sox. Luis Robert finished 2 for 4 with a double, a home run and two RBIs to lead the offensive showing. Lance McCullers (5.0 IP, 4 R, 4 H, 6 K) picked up the loss for the Astros.
Ahead of this Astros vs. White Sox matchup, here’s everything you need to prepare for Wednesday’s MLB action, including viewing options.
Houston Astros vs. Chicago White Sox odds, line and spread
MLB odds courtesy of BetMGM Sportsbook. Odds updated Wednesday at 3:17 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Favorite: Astros (-181, bet $181 to win $100)Underdog: White Sox (+150, bet $100 to win $150)Over/under: 8.5Astros vs. White Sox: Game time and live stream infoGame day: Wednesday, June 11, 2025Game time: 8:10 p.m. ETLocation: Houston, TexasStadium: Daikin ParkTV channel: SCHN and CHSNLive stream: Watch LIVE with Fubo! (Regional restrictions may apply)
Watch Astros vs. White Sox on Fubo!
Astros stats and trendsAstros betting recordsThis season, the Astros have won 25 out of the 45 games, or 55.6%, in which they’ve been favored.Houston has a record of 3-1 in games when sportsbooks favor them by at least -181 on the moneyline.The Astros have a 64.4% chance to win this game based on the implied probability of the moneyline.Games involving Houston have gone over the total set by oddsmakers in 26 of 66 chances this season.The Astros have an ATS record of 35-31-0 in 66 games with a spread this season.Ryan Gusto (Astros probable starter)Gusto gets the start for the Astros, his ninth of the season. He is 3-3 with a 4.78 ERA and 45 strikeouts in 43 1/3 innings pitched.His most recent appearance was on Wednesday against the Pittsburgh Pirates, when the right-hander went 4 1/3 innings, surrendering three earned runs while allowing eight hits.In 14 games this season, the 26-year-old has a 4.78 ERA and 9.3 strikeouts per nine innings, while giving up a batting average of .284 to opposing hitters.So far this season, Gusto does not have a quality start.Gusto has pitched five or more innings in a game two times this season entering this outing.He has had five appearances this season in which he kept his opponents to zero earned runs.He will take the hill against a White Sox offense that ranks 29th in MLB with 482 total hits (on a .222 batting average). The squad also slugs a collective .344 (29th in MLB) with 53 total home runs (28th in MLB).Gusto has thrown 2/3 of an inning without giving up an earned run on two hits against the White Sox this season.Astros batting statsThe Astros rank 20th in Major League Baseball with 65 home runs.The offense for Houston has a slugging percentage of .385 this season, 19th in MLB.The Astros rank 12th in MLB with a .251 team batting average.Houston has scored 263 runs (4.0 per game) this season, which ranks 22nd in MLB.The Astros have an on-base percentage of .316 this season, which ranks 15th in the league.Houston is one of the most-disciplined teams at the plate this season, ranking fourth with an average of 7.6 strikeouts per game.White Sox stats and trendsWhite Sox betting recordsThe White Sox have been victorious in 23, or 34.3%, of the 67 contests they have been chosen as underdogs in this season.Chicago has a win-loss record of 11-29 when favored by +150 or worse by bookmakers this year.The White Sox have an implied victory probability of 40% according to the moneyline set by sportsbooks for this matchup.Chicago and its opponents have gone over in 30 of its 67 games with a total set by sportsbooks this season.The White Sox have an against the spread record of 39-28-0 in 67 games with a line this season.Sean Burke (White Sox probable starter)Burke gets the start for the White Sox, his 12th of the season. He is 3-6 with a 4.03 ERA and 50 strikeouts in 67 2/3 innings pitched.His last appearance was on Thursday against the Detroit Tigers, when the righty tossed seven innings, surrendering two earned runs while giving up seven hits.The 25-year-old has put up an ERA of 4.03, with 6.7 strikeouts per nine innings in 13 games this season. Opposing hitters have a .241 batting average against him.Burke has five quality starts this year.Burke will try to continue a four-game streak of pitching five or more innings (he’s averaging 5.2 frames per outing).He has had two appearances this season that he kept his opponents to zero earned runs.He meets an Astros offense that ranks 22nd in the league with 263 total runs scored while batting .251 as a squad. His opponent has a collective .385 slugging percentage (19th in MLB play) and has hit a total of 65 home runs (20th in the league).Among pitchers who qualify in MLB play this season, the 25-year-old ranks 58th in ERA (4.03), 68th in WHIP (1.388), and 60th in K/9 (6.7).White Sox batting statsThe White Sox have hit 53 home runs this season, the third-lowest total in MLB action.This season, Chicago has the second-lowest slugging percentage in the majors (.344).The White Sox have the second-worst batting average in the majors (.222).Chicago is the fifth-lowest scoring team in MLB action averaging 3.5 runs per game (237 total).The White Sox rank 27th in MLB with a .297 on-base percentage.