At Rate Field on Friday, the Chicago White Sox (37-66) begin a three-game series against the Chicago Cubs (60-42), at 7:40 p.m. ET.
The Cubs are favored away from home (-187) versus the White Sox (+154). The starting pitchers are Shota Imanaga (7-3) for the Chicago Cubs, and Adrian Houser (5-2) for the Chicago White Sox.
The Cubs lost 8-4 against the Royals Wednesday, with Colin Rea getting credited with the loss. He threw five innings, giving up five earned runs on six hits while striking out three. Matt Shaw went 1 for 4 with a home run and an RBI to lead the Cubs offensively.
The White Sox took down the Rays 11-9 Wednesday. Colson Montgomery went 2 for 5 with a double, a home run and five RBIs, and Jordan Leasure got the win, pitching one inning without giving up an earned run on two hits, while striking out one.
Prepare for the Cubs vs. White Sox with everything you need to know ahead of Friday’s baseball action, including viewing options.
Chicago Cubs vs. Chicago White Sox odds, line and spread
MLB odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 9:18 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Favorite: Cubs (-187, bet $187 to win $100)Underdog: White Sox (+154, bet $100 to win $154)Over/under: 8Cubs vs. White Sox: Game time and live stream infoGame day: Friday, July 25, 2025Game time: 7:40 p.m. ETLocation: Chicago, IllinoisStadium: Rate FieldTV channel: CHSN and MARQLive stream: Watch LIVE with Fubo! (Regional restrictions may apply)
Watch Cubs vs. White Sox on Fubo!
Cubs stats and trendsCubs betting recordsThe Cubs have been favorites in 70 games this season and won 48 (68.6%) of those contests.The Cubs have a record of 13-1, a 92.9% win rate, when they’re favored by -187 or more by sportsbooks this season.The Cubs have a 65.2% chance to win this game based on the implied probability of the moneyline.Games involving the Cubs have gone over the total set by oddsmakers in 52 of 102 chances this season.The Cubs are 51-51-0 ATS in their 102 games with a spread this season.Shota Imanaga (Cubs probable starter)Imanaga makes the start for the Cubs, his 14th of the season. He is 7-3 with a 2.40 ERA and 53 strikeouts in 75 2/3 innings pitched.The left-hander last pitched on Saturday against the Boston Red Sox, when he threw seven scoreless innings while giving up five hits.The 31-year-old has an ERA of 2.40, with 6.4 strikeouts per nine innings, in 13 games this season. Opponents have a .192 batting average against him.Imanaga is aiming for his fourth quality start in a row.Imanaga will try to go five or more innings for his 13th straight appearance. He’s averaging 5.8 innings per outing.He has held his opponents without an earned run in five of his 13 appearances this season.He will take the hill against a White Sox squad that is batting .224 as a unit (29th in MLB). It is also slugging a collective .354 (29th in MLB) with 85 total home runs (28th in MLB).Cubs batting statsThe Cubs rank third in Major League Baseball with 152 home runs.Hitters for the Cubs have a combined .446 slugging percentage this season, which ranks second in MLB.The Cubs’ .256 batting average is among the best in baseball, ranking fourth in MLB.The Cubs have scored 537 runs this season, which ranks second in MLB.The Cubs have an OBP of .324 this season, which ranks sixth in MLB.The Cubs are one of the most disciplined teams at the plate this season, ranking fifth with an average of 7.7 strikeouts per game.White Sox stats and trendsWhite Sox betting recordsThe White Sox have been victorious in 36, or 35.6%, of the 101 contests they have been chosen as underdogs in this season.This year, the White Sox have won 14 of 51 games when listed as at least +154 or better on the moneyline.The White Sox have an implied victory probability of 39.4% according to the moneyline set by sportsbooks for this matchup.The White Sox and their opponents have hit the over in 44 of their 103 games with a total this season.The White Sox have an against the spread record of 59-44-0 in 103 games with a line this season.Adrian Houser (White Sox probable starter)Houser gets the start for the White Sox, his 11th of the season. He is 5-2 with a 1.89 ERA and 44 strikeouts over 62 2/3 innings pitched.The right-hander’s last appearance came on Saturday against the Pittsburgh Pirates, when he went 4 1/3 innings, surrendering three earned runs while allowing 10 hits.The 32-year-old has put up an ERA of 1.89, with 6.4 strikeouts per nine innings in 10 games this season. Opposing hitters have a .251 batting average against him.Houser is trying to pick up his ninth quality start of the year in this matchup.Houser is trying to record his 10th start of five or more innings this year in this game.In four of his 10 total appearances this season he has not given up an earned run.He will face a Cubs offense that ranks second in the league with 899 total hits (on a .256 batting average). The team also slugs a collective .446 (second in the league) with 152 total home runs (third in MLB action).White Sox batting statsThe White Sox have hit the third-fewest home runs in MLB play this season (85).So far this season, the White Sox have the second-lowest slugging percentage in the majors (.354).The White Sox have the second-worst batting average in the majors (.224).The White Sox are the fourth-lowest scoring team in MLB play averaging 3.7 runs per game (381 total).The White Sox’s .298 on-base percentage is the fourth-worst in the majors.