The Seattle Mariners (55-48) and the Los Angeles Angels (49-54) play the second game of a 4-game series Friday. First pitch from Angel Stadium in Anaheim is scheduled for 9:38 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Mariners vs. Angels odds and make our expert MLB picks and predictions for the best bets.

Season series: Mariners lead 4-2

The Mariners opened the series with a 4-2 victory at the Angels Thursday, cashing as +125 underdogs with the Under (9) hitting. CF Julio Rodríguez and LF Randy Arozarena each homered in the fifth inning, while 2B Jorge Polanco added a solo shot in the eighth.

Angels 1B Nolan Schanuel drove in a run with an RBI single in the first, and SS Zach Neto added another with a single in the seventh. Los Angeles has lost 4 straight games.

Mariners at Angels projected starters

RHP Bryan Woo vs. RHP José Soriano

Woo (8-5, 2.91 ERA) makes his 20th start. He has a 0.95 WHIP, 1.6 BB/9 and 8.6 K/9 through 120 2/3 innings.

Last start: Loss, 6 IP, 4 ER (5 R), 6 H, 1 BB, 6 K in 11-3 home defeat vs. Houston Astros Sunday2025 road stats: 4-3, 3.36 ERA (69 2/3 IP, 26 ER), 1.01 WHIP, 8.8 K/9 in 11 starts2024 vs. Angels: 0-0, 4.60 ERA (15 2/3 IP, 8 ER), 1.21 WHIP, 17 H, 2 BB, 6 K in 3 startsCareer vs. Angels: 1-0, 3.38 ERA (32 IP, 12 ER), 1.06 WHIP, 7.6 K/9 in 6 starts

Soriano (7-7, 3.83 ERA) makes his 22nd start. He has a 1.43 WHIP, 4.3 BB/9 and 7.7 K/9 through 120 innings.

Last start: Win, 7 IP, 2 ER, 6 H, 2 BB, 5 K in 8-2 victory at Philadelphia Phillies Sunday2025 home stats: 1-5, 5.65 ERA (51 IP, 32 ER), 1.69 WHIP, 9.9 K/9 in 10 starts2024 vs. Mariners: 2-0, 2.75 ERA (19 2/3 IP, 6 ER), 1.22 WHIP, 15 H, 9 BB, 13 K in 3 startsCareer vs. Mariners: 2-0, 2.70 ERA (26 2/3 IP, 8 ER), 1.24 WHIP, 7.4 K/9 in 3 starts and 5 relief appearances

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Mariners at Angels odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:08 p.m. ET.

Moneyline (ML): Mariners -125 (bet $125 to win $100) | Angels +105 (bet $100 to win $105)Run line (RL)/Against the spread (ATS): Mariners -1.5 (+135) | Angels +1.5 (-160)Over/Under (O/U): 8.5 (O: -102 | U: -118)Mariners at Angels picks and predictionsPrediction

Mariners 5, Angels 4

SEATTLE (-125) will probably hand the Angels their fifth straight loss Friday. Woo has allowed 2 ER or fewer in 5 of his last 6 starts, while Soriano has surrendered 5 or more in 2 of his last 3 outings at Angel Stadium. The Mariners are 4-2 against the Angels this season and have won 7 of their last 10 games overall.

BET MARINERS (-125).

Seattle -1.5 (+135) is a risky play, as only 1 of the Mariners’ last 6 games has resulted in a multi-run win for Seattle. On the flip side, Los Angeles +1.5 (-160) is too steep a price given Soriano’s 5.65 ERA at home.

PASS on the run line.

Soriano has allowed 14 ER over 13 innings in his last 3 home starts, with the Over cashing in 2 of those outings. The Angels, meanwhile, have scored 5 or more runs in 7 of their last 12 games, contributing to an 8-3-1 Over record during that span.

BET OVER 8.5 (-102).

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