The Arizona Diamondbacks (51-55) and Detroit Tigers (61-46) begin a 3-game series Monday. First pitch from Comerica Park in Detroit is set for 6:40 p.m. Let’s analyze BetMGM Sportsbook’s MLB odds around the Diamondbacks vs. Tigers odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Tigers won 2 of 3 last season

The Diamondbacks opened their 9-game road trip with a rough series loss in Pittsburgh, managing just 1 run total across the 3-game set against the Pirates. They won the opener 1-0, but were shut out 2-0 Saturday and 6-0 Sunday. Arizona lost the finale as +134 underdogs as the Under (7.5) cashed.

The Tigers ended their 6-game skid Sunday with a 10-4 win over the Toronto Blue Jays as -113 home favorites as the Over (8.5) cashed. Starter Jack Flaherty delivered 6 shutout innings with 7 strikeouts and 2B Gleyber Torres powered the offense, going 2-for-4 with a home run and 4 RBIs.

Diamondbacks at Tigers projected starters

LHP Eduardo Rodriguez vs. RHP Troy Melton

Rodriguez (3-6, 5.50 ERA) is making his 18th start. He has a 1.65 WHIP, 3.3 BB/9 and 9.7 K/9 through 86 2/3 innings.

Last start: No-decision, 6 1/3 IP, 0 ER, 6 H, 3 BB, 3 K in 3-1 home loss against Houston Astros Tuesday2025 road stats: 2-4, 5.61 ERA (43 1/3 IP, 27 ER), 1.73 WHIP, 11.6 K/9 in 9 startsCareer vs. Diamondbacks: 5-1, 2.54 ERA (39 IP, 11 ER), 1.18 WHIP, 9.9 K/9 in 7 starts; last faced them in 2021

Melton (0-1, 10.80 ERA) is making his second career start. The 24-year-old fourth-round draft pick (2022) was called up on July 21

MLB debut: 5 IP, 6 ER, 7 H, 2 BB, 7 K in 6-1 road loss against Pittsburgh Pirates Wednesday2025 minor league stats: 2-3, 2.99 ERA with a 1.23 WHIP, 2.4 BB/9 and 12.1 K/9 through 75 1/3 innings with AA Erie SeaWolves and AAA Toledo Mudhens

Win your fantasy baseball league with BaseballHQ.com. For decades, BHQ has been helping players just like you win! BHQ offers full-season subscriptions. Sign up today and start winning!

Diamondbacks at Tigers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:04 a.m. ET.

Moneyline (ML): Diamondbacks +110 (bet $100 to win $110) | Tigers -135 (bet $135 to win $100)Run line (RL)/Against the spread (ATS): Diamondbacks +1.5 (-200) | Tigers -1.5 (+165)Over/Under (O/U): 9 (O: +100 | U: -120)Diamondbacks at Tigers picks and predictionsPrediction

Diamondbacks 7, Tigers 5

BET DIAMONDBACKS (+110).

The Diamondbacks are in a favorable spot to take Monday’s series opener in Detroit. Arizona sends Rodriguez to the mound, who’s been solid on the road, allowing just 5 earned runs over his last 3 road starts (14 2/3 IP). He’s coming off a strong outing, holding Houston scoreless through 6 1/3 innings. On the other side, Detroit rookie Melton makes his second career start—and first at Comerica Park—after giving up 6 earned runs in 5 innings in his debut. That home crowd pressure won’t make things easier.

The Tigers have dropped 7 of their last 10 games at home and enter the week struggling at the plate, hitting an MLB-worst .197 over the last 15 days. While Detroit looked better on Sunday, it’s tough to trust this offense to stay hot. At plus odds, the value lies with Arizona to grab the series opener on the road.

PASS.

I’m going to keep my wager to the run line.

BET OVER 9 (+100).

The Over has hit in 7 of the last 8 games between the Tigers and Diamondbacks, and recent trends support more scoring Monday. The Over is 3-2-1 in Detroit’s last 6 games and has cashed in 4 of Rodriguez’s last 6 starts. Expect another high-scoring affair in this series opener.

Play our free daily Pick’em Challenge and win! Play now!

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow @DrewPhelps05 on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.