The Arizona Diamondbacks (51-56) visit the Detroit Tigers (62-46) Tuesday for the second game of their 3-game series. First pitch from Comerica Park is set for 6:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Diamondbacks vs. Tigers odds and make our expert MLB picks and predictions for the best bets.

Season series: Tigers lead 1-0

The Diamondbacks lost the series-opening game 5-1 Monday, closing as a +117 moneyline underdog. CF Alek Thomas had the lone RBI for Arizona. The Diamondbacks have now lost 3 games in a row and 6 of their last 7 contests. They are 4-6 since the All-Star break and have dropped to fourth in the NL West, 11 games out of first place.

The Tigers, who sit atop the AL Central, are trying to right the ship after going 1-8 in their first 9 games following the break. They have rattled off 2 straight wins, scoring 15 total runs. On Monday, Detroit was led by rookie pitcher Troy Melton, who pitched 7 scoreless innings in his second career start (5 H, 0 BB, 5 K). C Dillon Dingler, 3B Andy Ibanez and 1B Spencer Torkelson each had multiple hits and 1 RBI.

Diamondbacks at Tigers projected starters

RHP Brandon Pfaadt vs. RHP Casey Mize

Pfaadt (10-6, 4.76 ERA) makes his 22nd start. He has a 1.26 WHIP, 2.0 BB/9 and 7.7 K/9 through 111 2/3 innings.

Last start: No-decision, 5 1/3 IP, 2 ER, 5 H, 2 BB, 5 K in 4-3 home loss vs. Houston Astros Wednesday2025 road stats: 4-3, 5.94 ERA (53 IP, 35 ER), 1.25 WHIP, 6.8 K/9 in 10 startsFirst time facing Tigers in his 3-year career

Mize (9-4, 3.40 ERA) makes his 18th start. He has a 1.28 WHIP, 2.2 BB/9 and 8.0 K/9 through 92 2/3 innings.

Last start: Loss, 4 IP, 4 ER, 10 H, 1 BB, 5 K in 8-5 road defeat vs. Pittsburgh Pirates last Tuesday2025 home stats: 5-1, 3.23 ERA (39 IP, 14 ER), 1.10 WHIP, 7.6 K/9 in 7 startsHas not faced Diamondbacks in his 5-year career

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Diamondbacks at Tigers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 11:50 p.m. ET.

Moneyline (ML): Diamondbacks +120 (bet $100 to win $120) | Tigers -145 (bet $145 to win $100)Run line (RL)/Against the spread (ATS): Diamondbacks +1.5 (-175) | Tigers -1.5 (+145)Over/Under (O/U): 8.5 (O: -115 | U: -105)Diamondbacks at Tigers nickname picks and predictionsPrediction

Tigers 5, Diamondbacks 2

PASS.

While the Tigers (-145) have some moneyline value, the preferred play is the home side’s spread. The Diamondbacks (+120) aren’t worth the risk here, given how poor Pfaadt has been on the road.

BET TIGERS -1.5 (+145).

The Tigers have been among the best teams on the run line both at home and as a favorite. As a favorite, they are 33-39 ATS, sitting fifth in the majors. Detroit has gone 29-26 ATS at home, ranking eighth.

Pfaadt has given up at least 2 ERs in all but one road appearance this season. Couple that with the Diamondbacks having scored a mere 2 runs in their last 4 games combined, and there’s a strong case for Detroit.

Back TIGERS -1.5 (+145).

BET UNDER 8.5 (-105).

Neither offense has been overly consistent, and both sides are trending toward the Under. The Tigers are 1-2-1 O/U in their last 4 games and 3-7-1 O/U in their last 11 contests. They have scored more than 4 runs just twice in their last 6 games.

Similarly, the Diamondbacks have totaled 9 runs in their previous 7 contests, going 0-6-1 O/U. Considering those trends, back UNDER 8.5 (-105).

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