The Arizona Diamondbacks (51-57) visit the Detroit Tigers (63-46) Wednesday in the finale of their 3-game series. First pitch from Comerica Park is set for 1:10 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s MLB odds around the Diamondbacks vs. Tigers odds and make our expert MLB picks and predictions for the best bets.

Season series: Tigers lead 2-0

The Diamondbacks, despite jumping out to a 2-0 lead after the first 3 innings, lost 12-2 Tuesday in the second game of the series after losing the Monday opener 5-1. They have dropped 4 straight games and 7 of their last 8 contests. Arizona is just 2-7 in its last 9 road games.

The Tigers were led in their victory Tuesday by SS Zach McKinstry, who went 2-for-5 with 4 RBIs. Detroit has ripped off 3 straight wins, scoring double figures in 2 of those performances. However, it is still just 3-6 over its last 9 games.

Diamondbacks at Tigers projected starters

RHP Ryne Nelson vs. RHP Chris Paddack

Nelson (6-2, 3.29 ERA) makes his 13th start (23rd appearance). He has a 1.02 WHIP, 2.8 BB/9 and 7.3 K/9 through 90 1/3 innings.

Last start: No-decision, 6 IP, 0 ER, 1 H, 2 BB, 4 K in 1-0 home win vs. Pittsburgh Pirates Friday2025 road stats: 1-1, 4.89 ERA (38 2/3 IP, 21 ER), 1.22 WHIP, 7.7 K/9 in 6 starts and 4 relief appearancesCareer vs. Tigers: 1-1, 7.45 ERA (9 2/3 IP, 8 ER), 1.86 WHIP, 7.4 K/9 in 2 starts

Paddack (3-9, 4.95 ERA) makes his 22nd start and his first with the Tigers, who acquired him in a trade from the Minnesota Twins. He has a 1.28 WHIP, 2.2 BB/9 and 6.7 K/9 through 111 innings.

Last start: No-decision, 6 IP, 1 ER, 4 H, 0 BB, 8 K in Twins 4-3 road loss vs. LA Dodgers Wednesday2025 home stats: 1-4, 4.34 ERA (47 2/3 IP, 23 ER), 1.32 WHIP, 6.2 K/9 in 9 startsCareer vs. Diamondbacks: 2-3, 3.22 ERA (44 2/3 IP, 16 ER), 1.19 WHIP, 9.1 K/9 in 9 starts

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Diamondbacks at Tigers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:34 a.m. ET.

Moneyline (ML): Diamondbacks +115 (bet $100 to win $115) | Tigers -140 (bet $140 to win $100)Run line (RL)/Against the spread (ATS): Diamondbacks +1.5 (-190) | Tigers -1.5 (+155)Over/Under (O/U): 9 (O: +100 | U: -120)Diamondbacks at Tigers picks and predictionsPrediction

Diamondbacks 4, Tigers 3

BET DIAMONDBACKS (+115).

Despite their recent struggles, the Diamondbacks have only been swept four times this season and often are able to win at least 1 games of a series. At 17-21, Arizona sits in the top half of the league as an underdog. It is 7-1 in Nelson’s last 8 starts as well.

The Tigers have allowed at least 6 runs in 5 of their last 8 games and will be starting the recently acquired Paddack. They are just 3-7 in their last 10 at home.

Back DIAMONDBACKS (+115).

PASS.

There’s no great value here. The Diamondbacks (-190) are far too expensive to take on the run line, while the Tigers (+155) are too risky as a favorite.

BET UNDER 9 (-120).

The Under is the play here. The Diamondbacks have gone Under in 6 of their last 7 games, scoring 3 or fewer in each of those. Their offense has been absent over the last 10 days.

Meanwhile, the Tigers will be facing a strong starting pitcher in Nelson and have scored 4 or fewer runs in 4 of their last 7 games. Back UNDER 9 (-120).

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