The Kansas City Royals (56-58) and the Boston Red Sox (64-51) wrap up a 3-game series Wednesday at Fenway Park in Boston. First pitch is scheduled for 7:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Royals vs. Red Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: Red Sox lead 4-1

The Red Sox extended their winning streak to 7 games Tuesday night with a 6-2 victory over the Royals, cashing as heavy -225 favorites. The Over (7.5) also hit, improving to 5-2 during Boston’s run. The Red Sox offense has been rolling, piling up 50 runs over the streak — an average of 7.2 runs per game (RPG).

Kansas City has dropped 3 of its last 4, with the Over cashing in each of the past 3 contests. The Royals are 5-6 in their last 11 road games, but the Over has gone 7-2 in their past 9 away from home.

On Tuesday, 3B Maikel Garcia paced Kansas City’s offense, going 2-for-3 with a run scored and his 50th RBI of the season. Boston’s top 4 hitters carried the attack, combining to go 6-for-14 with 2 doubles, 2 walks, 4 runs scored and 6 RBIs. SS Trevor Story drove in 3 runs, quietly pushing his season total to 72.

Royals at Red Sox projected starters

RHP Michael Wacha vs. RHP Dustin May

Wacha (5-9, 3.38 ERA) makes his 23rd start. He has a 1.16 WHIP, 2.5 BB/9 and 6.8 K/9 through 125 1/3 innings.

Last start: Win, 8 IP, 1 ER, 3 H (1 solo HR), 0 BB, 5 K in 9-3 victory at Toronto Blue Jays Friday2025 road stats: 3-5, 4.10 ERA (63 2/3 IP, 29 ER), 1.18 WHIP, 5.2 K/9, 8 HR in 11 startsHasn’t faced Red Sox in 2025Career vs. Red Sox: 2-1, 2.14 ERA (21 IP, 5 ER), 1.19 WHIP, 19 H, 1 HR, 6 BB, 21 K in 4 starts

May (6-7, 4.85 ERA with LA Dodgers) makes his 19th start and 20th appearance. He has a 1.35 WHIP, 3.7 BB/9 and 8.4 K/9 through 104 innings.

Was acquired Thursday from DodgersLast outing: Loss, 5 IP, 4 ER, 5 H, 1 HR, 0 BB, 5 K in 4-3 setback in Boston July 272025 home stats: 5-2, 3.00 ERA (57 IP, 19 ER), 1.18 WHIP, 9.2 K/9, 7 HR in 9 starts (10 appearances)Career vs. Royals: 1 road start (June 27), no-decision, 4 IP, 4 ER, 6 H (1 HR), 3 BB, 3 K in 5-4 victory

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Royals at Red Sox odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:06 a.m. ET.

Moneyline (ML): Royals +125 (bet $100 to win $125) | Red Sox -150 (bet $150 to win $100)Run line (RL)/Against the spread (ATS): Royals +1.5 (-175) | Red Sox -1.5 (+145)Over/Under (O/U): 9 (O: -105 | U: -115)Royals at Red Sox picks and predictionsPrediction

Red Sox 6, Royals 5

The RED SOX (-150) are worth a look behind May in his team debut. Boston has been red hot, so he might not even have to be perfect, as the offense has been on fire lately. Boston has averaged 6.2 RPG in the past 10 games, so keep riding the wave until it crashes for the Red Sox.

The Royals have scored 4 runs or fewer in 5 of their last 10 games, while allowing at least 4 runs in each of the past 4 contests and in 7 of their last 10 overall.

The ROYALS +1.5 (-175) aren’t priced out of line if you’d like a little bit of insurance.

May is a bit of a wild card. He could have some nerves, there might be a little bit of rust since he hasn’t pitched in 2 weeks, and Wacha has done a decent job at times on the road.

OVER 9 (-105) is worth playing lightly.

The Over has hit in 3 straight for the Royals and is 6-2 over their last 8 games. It’s also 3-3 in Wacha’s past 6 starts.

For Boston, the Over has cashed in 5 of the last 7 contests, including a 3-1 mark in the past 4 at Fenway.

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