The Cincinnati Reds (67-60) and the Los Angeles Angels (60-66) wrap up a 3-game interleague series Wednesday at Angel Stadium in Anaheim. First pitch is scheduled for 9:38 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s MLB odds around the Reds vs. Angels odds and make our expert MLB picks and predictions for the best bets.

Season series: Reds lead 2-0

After a 4-1 win Monday, the Reds picked up a 6-4 road win against the Angels Tuesday night, clinching the series victory, regardless of the result of Wednesday’s game. 1B Miguel Andujar went 3-for-4 with a double and 2 RBIs, while RF Noelvi Marte was 2-for-4 with a double, homer and 2 RBIs.

For the Angels, OF Jo Adell was the offensive star, going 3-for-4 with a pair of solo homers, while DH Mike Trout was 2-for-3 with a double, walk and run scored. However, the Angels also had 15 strikeouts in 35 at-bats, including 12 against Cincinnati RHP Hunter Greene.

Cincinnati kept pace with the New York Mets, staying 1 game behind for the final NL Wild Card spot with 35 games to play. The Reds have picked up 5 wins in the past 7 games, while posting a 7-3 mark in the past 10 contests. Despite the Over (8.5) cashing Tuesday, the Under has connected at a 11-5-1 clip in the past 17 games, too.

The Angels have dropped 4 of the past 5 games, while allowing at least 4 runs in 13 consecutive outings since Aug. 5. The Over is now 10-2-1 in the past 13 contests.

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Reds at Angels projected starters

RHP Nick Martinez vs. LHP Yusei Kikuchi

Martinez (10-9, 4.73 ERA) makes his 25th start and 28th appearance. He has a 1.23 WHIP, 2.1 BB/9 and 6.4 K/9 through 139 innings.

Last start: No-decision, 2 2/3 IP, 6 R (5 ER), 9 H (2 HR), 0 BB, 1 K in 10-8 home loss vs. Milwaukee Brewers FridayLast 7 games: 4-0, 4.32 ERA (33 1/3 IP, 16 ER), 9 BB, 25 K, 1.29 WHIP in 6 starts and 1 relief appearance2025 road stats: 4-5, 4.52 ERA (67 2/3 IP, 34 ER), 9 HR, 15 BB, 42 K, 1.30 WHIP in 13 games (11 starts)Career vs. Angels: 3-3, 3.02 ERA (59 2/3 IP, 20 ER), 8 HR, 14 BB, 36 K, 1.04 WHIP, 5.4 K/9 in 8 starts (13 appearances)

Kikuchi (6-8, 3.52 ERA) makes his 27th start. He has a 1.44 WHIP, 3.8 BB/9 and 9.4 K/9 through 143 innings.

Last start: Loss, 4 IP, 4 ER, 5 H (2 HR), 3 BB, 3 K in 10-3 road loss vs. Athletics FridayLast 7 games: 3-2, 5.05 ERA (35 2/3 IP, 20 ER), 13 BB, 39 K, 1.63 WHIP in 7 starts2025 home stats: 5-2, 2.40 ERA (75 IP, 20 ER), 10 HR, 24 BB, 76 K, 1.24 WHIP in 13 startsCareer vs. Reds (1 start): No-decision, 4 1/3 IP, 2 ER, 2 H, 3 BB, 7 K in 3-2 home loss with Blue Jays (May 22, 2022)

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Reds at Angels odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:34 a.m. ET.

Moneyline (ML): Reds +105 (bet $100 to win $105) | Angels -125 (bet $125 to win $100)Run line (RL)/Against the spread (ATS): Reds +1.5 (-200) | Angels -1.5 (+165)Over/Under (O/U): 8.5 (O: -120 | U: +100)Reds at Angels picks and predictionsPrediction

Angels 5, Reds 4

The ANGELS (-125) are worth playing in the interleague series finale, as they look to salvage at least 1 game after dropping the first 2 contests.

Kikuchi has been money at home, and Martinez, while pitching somewhat well lately, has had his struggles on the road. He is 4-0 in his past 7 games, but it’s mostly a result of strong offensive support, not necessarily dominant pitching.

The Reds +1.5 (-200) will cost you 2 times your potential return, if you would like some insurance. That’s way too costly, and if you like Cincinnati, just take it straight up.

AVOID.

OVER 8.5 (-120) worth playing lightly, but roll with a half-unit play at best.

The Over cashed in Tuesday’s game, which was the result of 5 combined runs in the final 3 innings. While the Over is 3-3 in the past 6 road games for the Reds, and there isn’t much to glean there, the total has gone high at a 10-2-1 clip in the previous 13 outings.

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