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Cal Raleigh and Gavin Sheets will look to continue their recent offensive production when the Seattle Mariners and San Diego Padres hit the field at T-Mobile Park on Wednesday, at 4:10 p.m. ET. The Mariners are -114 moneyline favorites in this matchup against the Padres (-106). San Diego is a 1.5-run favorite (at +156 odds). The over/under is 8 runs for the matchup.
Take a look at everything you need from a betting perspective on the Mariners-Padres game, regarding the run line, moneyline and total, plus expert picks.
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Dodgers vs. Padres Highlights | MLB on FOX 
Check out the best moments between the Los Angeles Dodgers and San Diego Padres.
Mariners vs. Padres Game Information & OddsWhen: Wednesday, August 27, 2025 at 4:10 p.m. ETWhere: T-Mobile Park in Seattle, WashingtonHow to watch on TV: MLB Network, ROOT Sports NW, and SDPA Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Mariners -114 -106 8 -112 -108 -1.5 -190 +156 Mariners vs. Padres PredictionScore Prediction: Mariners 5, Padres 4Total Prediction: Under 8 runsWin Probabilities: Mariners 53%, Padres 47%Mariners vs. Padres Betting InsightsThe Mariners have been favorites in 90 games this season and won 50 (55.6%) of those contests.Seattle has a record of 47-38, a 55.3% win rate, when favored by -114 or more by sportsbooks this season.The bookmakers’ moneyline implies a 53.3% chance of a victory for the Mariners.The Padres have been chosen as underdogs in 61 games this year and have walked away with the win 31 times (50.8%) in those games.This season, San Diego has been victorious 29 times in 59 chances when named as an underdog of at least -106 or longer on the moneyline.The Padres have an implied victory probability of 51.5% according to the moneyline set by oddsmakers for this matchup.Mariners Recent Betting PerformanceThe Mariners were the moneyline favorite in six of their last 10 games, and finished 3-3 in those matchups.Over their last 10 outings — all had a set run total — the Mariners and their opponents combined to go over the total seven times.The Mariners are 3-7-0 against the spread over their past 10 games.Mariners Recent Stats Stat Avg/Total Record 4-6 Runs Per Game 5.2 HR 16 ERA 6.17 K/9 9.5 Mariners Player InsightsRaleigh has a team-high 50 home runs and 107 runs batted in.Of all hitters in MLB, Raleigh’s home run total ranks him first, and his RBI tally puts him second.Raleigh has collected a hit in two straight games. In his last five games he is batting .200 with three home runs and five RBIs.Josh Naylor is hitting .284 to pace his team.Naylor is 89th in homers in the majors, and 34th in RBI.Naylor has four straight games with at least one hit. In his last five games he is batting .313 with a double, a home run, a walk and four RBIs.Julio Rodriguez has 24 doubles, four triples, 25 home runs and 33 walks while hitting .259.Rodriguez will look to build on his two-game hitting in this matchup. During his last five outings he is hitting .278 with a double, a home run, a walk and three RBIs.Eugenio Suarez is batting .234 with 23 doubles, 40 home runs and 36 walks.Padres Recent Betting PerformanceIn five games over the last 10 matchups when set as underdogs by bookmakers, the Padres had a record of 2-3.The Padres and their opponents have combined to hit the over five times in their last 10 games with a total.The Padres have six wins against the spread in their last 10 chances.Padres Recent Stats Stat Avg/Total Record 5-5 Runs Per Game 4.3 HR 11 ERA 3.83 K/9 8.8 Padres Player InsightsFernando Tatis Jr. has 25 doubles, two triples, 18 home runs and 79 walks while batting .263.Among all hitters in MLB, Tatis is 70th in home runs and 100th in RBI.Manny Machado has hit 21 home runs with 78 RBI while hitting .289. Those numbers are pace the clubhouse.Machado is currently 46th in home runs and 21st in RBI in the major leagues.Luis Arraez is batting .286 with 29 doubles, four triples, six home runs and 26 walks.Xander Bogaerts is batting .262 with 29 doubles, 10 home runs and 48 walks.Athletics vs. Mariners Highlights | MLB on FOX 
Check out the best moments between the Athletics and the Seattle Mariners.
FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.
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