On Friday, a series opener is on the schedule, with the Boston Red Sox (78-63) visiting the Arizona Diamondbacks (70-71) at 9:40 p.m. ET.

The Red Sox are a favorite (-128) against the Diamondbacks (+107). The scheduled starters are Payton Tolle for the Boston Red Sox, and Eduardo Rodriguez (6-8) for the Arizona Diamondbacks.

The Red Sox lost 8-1 to the Guardians Wednesday, with Brennan Bernardino (2/3 of an inning, giving up one earned run on one hit) on the hook for the loss. Romy Gonzalez went 2 for 4 to lead the Red Sox offensively in the defeat.

Wednesday, the Diamondbacks knocked off the Rangers 2-0. Zac Gallen was the winning pitcher after throwing six innings without giving up an earned run on four hits, while striking out five. Corbin Carroll led the Diamondbacks’ offense, going 1 for 2 with a double.

Get ready for the Red Sox vs. Diamondbacks with everything you need to know before Friday’s game, including viewing options.

Boston Red Sox vs. Arizona Diamondbacks odds, line and spread

MLB odds courtesy of BetMGM Sportsbook. Odds updated Friday at 3:16 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Favorite: Red Sox (-128, bet $128 to win $100)Underdog: Diamondbacks (+107, bet $100 to win $107)Over/under: 8.5Red Sox vs. Diamondbacks: Game time and live stream infoGame day: Friday, September 5, 2025Game time: 9:40 p.m. ETLocation: Phoenix, ArizonaStadium: Chase FieldTV channel: ARID and NESNLive stream: Watch LIVE with Fubo! (Regional restrictions may apply)

Watch Red Sox vs. Diamondbacks on Fubo!

Red Sox stats and trendsRed Sox betting recordsThe Red Sox have been favorites in 87 games this season and won 52 (59.8%) of those contests.This season Boston has won 31 of its 54 games, or 57.4%, when favored by at least -128 on the moneyline.The implied probability of a win from the Red Sox, based on the moneyline, is 56.1%.Boston and its opponents have hit the over in 68 of its 140 games with a total this season.The Red Sox are 73-67-0 against the spread in their 140 chances this season.Payton Tolle (Red Sox probable starter)The Red Sox will send Tolle (0-0) to the mound to make his second start of the season.In his most recent time out on Friday, the left-hander tossed 5 1/3 innings against the Pittsburgh Pirates, allowing two earned runs while surrendering three hits.Opposing hitters have a collective batting average of only .158 against him this season. He has a 3.38 ERA and 13.5 strikeouts per nine innings over his one appearance.He will face a Diamondbacks offense that ranks sixth in the league with 692 runs while batting .249 as a squad. It has a collective .436 slugging percentage (second in MLB play) and has hit a total of 194 home runs (fifth in MLB).Red Sox batting statsThe Red Sox’s 169 home runs rank 13th in Major League Baseball.Hitters for Boston have a combined .426 slugging percentage this season, which ranks eighth in MLB.The Red Sox have a team batting average of .254 this season, which ranks fourth among MLB teams.Boston is among the highest-scoring teams in the majors, ranking fifth with 696 total runs this season.The Red Sox have an OBP of .325 this season, which ranks seventh in MLB.Boston ranks 27th in strikeouts per game (8.8) among MLB offenses.Diamondbacks stats and trendsDiamondbacks betting recordsThe Diamondbacks have been victorious in 27, or 47.4%, of the 57 contests they have been chosen as underdogs in this season.Arizona has a win-loss record of 21-19 when favored by +107 or worse by bookmakers this year.The Diamondbacks have an implied victory probability of 48.3% according to the moneyline set for this matchup.Arizona’s games have gone over the total in 66 of its 140 opportunities.In 140 games with a line this season, the Diamondbacks have a mark of 71-69-0 against the spread.Eduardo Rodríguez (Diamondbacks probable starter)Rodriguez gets the start for the Diamondbacks, his 25th of the season. He is 6-8 with a 5.40 ERA and 120 strikeouts through 125 2/3 innings pitched.His most recent appearance was on Sunday against the Los Angeles Dodgers, when the left-hander tossed six scoreless innings while giving up four hits.The 32-year-old has a 5.40 ERA and 8.6 strikeouts per nine innings in 24 games this season, while allowing a batting average of .297 to opposing hitters.Rodriguez has registered six quality starts this year.Rodriguez is looking to pick up his 18th start of five or more innings this season in this game.He has held his opponents without an earned run in three of his 24 appearances this season.He will match up with a Red Sox offense that ranks third in the league with 1231 total hits (on a .254 batting average). The squad also slugs a collective .426 (eighth in the league) with 169 total home runs (13th in MLB action).Diamondbacks batting statsThe Diamondbacks rank fifth in MLB action with 194 home runs. They average 1.4 per game.So far this season, Arizona ranks second in the majors with a .436 slugging percentage.The Diamondbacks have the 14th-ranked batting average in the league (.249).The offense for Arizona is No. 6 in MLB, scoring 4.9 runs per game (692 total runs).The Diamondbacks’ .322 on-base percentage ranks eighth-best in MLB.

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