The Chicago White Sox (14-30) will visit the Chicago Cubs (25-19), Friday at 2:20 p.m. ET, in the first of a three-game series.
The White Sox are an away underdog (+188) at the Cubs (-228). The Cubs will start Cade Horton (1-0) versus the White Sox and Shane Smith (1-2).
The Cubs lost 3-1 against the Marlins Wednesday, with Jameson Taillon taking the loss. He threw six innings, giving up three earned runs on four hits while striking out seven. Seiya Suzuki went 1 for 4 with a home run and an RBI to lead the Cubs offensively.
Yesterday, the White Sox fell to the Reds 7-1. Bryse Wilson was the losing pitcher after he went 5 1/3 innings, giving up seven earned runs on 10 hits while striking out three. Miguel Vargas led the White Sox’s offense, going 2 for 4 with an RBI.
Ahead of watching this Cubs vs. White Sox matchup, here’s what you need to know about Friday’s action on the diamond, including viewing options.
Chicago Cubs vs. Chicago White Sox odds, line and spread
MLB odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 6:16 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Favorite: Cubs (-228, bet $228 to win $100)Underdog: White Sox (+188, bet $100 to win $188)Over/under: 12.5Cubs vs. White Sox: Game time and live stream infoGame day: Friday, May 16, 2025Game time: 2:20 p.m. ETLocation: Chicago, IllinoisStadium: Wrigley FieldTV channel: MLB Network, MARQ, and CHSNLive stream: Watch LIVE with Fubo! (Regional restrictions may apply)
Watch Cubs vs. White Sox on Fubo!
Cubs stats and trendsCubs betting recordsThe Cubs have entered the game as favorites 25 times this season and won 16, or 64%, of those games.The Cubs have played as a favorite of -228 or more twice this season and won both games.The oddsmakers’ moneyline implies a 69.5% chance of a victory for the Cubs.Games involving the Cubs have gone over the total set by oddsmakers in 26 of 44 chances this season.In 44 games with a spread this season, the Cubs are 22-22-0 ATS.Cade Horton (Cubs probable starter)Horton gets the call to start for the Cubs, his first this season.The righty will make his MLB debut. He’s 23 years old.In one appearance this season, he has compiled a 6.75 ERA and averages 11.3 strikeouts per nine innings while opposing batters are hitting .250 against him.The White Sox have MLB’s 28th-ranked scoring offense (149 total runs) and have racked up a .214 batting average as a team while hitting 32 home runs (28th in the league) this season.Cubs batting statsThe Cubs’ 63 home runs rank third in Major League Baseball.Hitters for the Cubs have a combined .436 slugging percentage this season, which ranks fourth in MLB.The Cubs rank 13th in MLB with a .250 team batting average.The Cubs have scored 244 runs this season, which ranks second in MLB.The Cubs are among the best in the league at getting on base, ranking ninth with an OBP of .327.The Cubs rank 12th with an average of 8.0 strikeouts per game.White Sox stats and trendsWhite Sox betting recordsThe White Sox have been chosen as underdogs in 44 games this year and have walked away with the win 14 times (31.8%) in those games.This year, the White Sox have won two of 17 games when listed as at least +188 or better on the moneyline.Bookmakers have implied with the moneyline set for this matchup that the White Sox have a 34.7% chance of pulling out a win.The White Sox and their opponents have hit the over in 18 of their 44 games with a total this season.The White Sox are 24-20-0 against the spread in their 44 games that had a posted line this season.Shane Smith (White Sox probable starter)The White Sox will send Smith (1-2) out to make his ninth start of the season. He is 1-2 with a 2.08 ERA and 38 strikeouts over 43 1/3 innings pitched.In his most recent time out on Saturday against the Miami Marlins, the righty tossed six scoreless innings while surrendering four hits.The 25-year-old has amassed a 2.08 ERA and 7.9 strikeouts per nine innings over eight games this season, while allowing a batting average of .205 to opposing hitters.Smith has registered three quality starts this year.Smith will try to build on a five-game streak of pitching five or more innings (he’s averaging 5.4 innings per outing).He has made three appearances this season in which he did not give up an earned run.He will match up with a Cubs offense that ranks seventh in the league with 380 total hits (on a .250 batting average). The team also slugs a collective .436 (fourth in the league) with 63 total home runs (third in MLB play).White Sox batting statsThe White Sox have hit 32 home runs this season, the third-lowest total in MLB play.So far this year, the White Sox’s .324 slugging percentage is the lowest average in the majors.The White Sox have the second-worst batting average in the majors (.214).The offense for the White Sox is No. 28 in baseball scoring 3.4 runs per game (149 total runs).The White Sox’s .289 on-base percentage is the third-worst in the majors.