A pair of clubs in the AL Central — the Cleveland Guardians (78-71) and the Detroit Tigers (85-65) — meet on Tuesday at 6:40 p.m. ET, at Comerica Park.
The Guardians (+120 underdog on the moneyline to win) visit the Tigers (-141). The Tigers will start Casey Mize (14-5) versus the Guardians and Joey Cantillo (5-3).
The Tigers won their last game against the Marlins on Sunday by a 2-0 score. Spencer Torkelson went 1 for 2 to lead them offensively. Keider Montero picked up the win on the strength of five innings without giving up an earned run on three hits, while striking out five.
The Guardians picked up a 3-2 victory against the White Sox Sunday. Bo Naylor (2 for 3 with a double, a home run and three RBIs) led the way offensively, while Matt Festa got the win on the mound after going one inning without giving up a hit or an earned run while striking out three.
Prepare for the Tigers vs. Guardians with everything you need to know ahead of Tuesday’s game, including viewing options.
Detroit Tigers vs. Cleveland Guardians odds, line and spread
MLB odds courtesy of BetMGM Sportsbook. Odds updated Monday at 3:17 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Favorite: Tigers (-141, bet $141 to win $100)Underdog: Guardians (+120, bet $100 to win $120)Over/under: 7.5Tigers vs. Guardians: Game time and live stream infoGame day: Tuesday, September 16, 2025Game time: 6:40 p.m. ETLocation: Detroit, MichiganStadium: Comerica ParkTV channel: FDSDET and CLEGLive stream: Watch LIVE with Fubo! (Regional restrictions may apply)
Watch Tigers vs. Guardians on Fubo!
Tigers stats and trendsTigers betting recordsThe Tigers have entered the game as favorites 104 times this season and won 63, or 60.6%, of those games.Detroit has a record of 44-20, a 68.8% win rate, when favored by -141 or more by sportsbooks this season.Bookmakers have implied with the moneyline set for this matchup that the Tigers have a 58.5% chance to win.Detroit and its opponents have gone over the total this season in 79 of 150 opportunities.In 150 games with a spread this season, the Tigers are 72-78-0 ATS.Casey Mize (Tigers probable starter)Mize (14-5 with a 3.83 ERA and 118 strikeouts in 131 2/3 innings pitched) makes the start for the Tigers, his 26th of the season.In his most recent time out on Tuesday, the right-hander threw six innings against the New York Yankees, allowing two earned runs while surrendering four hits.The 28-year-old has a 3.83 ERA and 8.1 strikeouts per nine innings in 25 games this season, while allowing a batting average of .264 to his opponents.Mize heads into the outing with eight quality starts under his belt this year.Mize will try to prolong a three-game streak of going five or more innings (he’s averaging 5.2 frames per outing).He has had two appearances this season in which he kept his opponents to zero earned runs.He will take the hill against a Guardians squad that is batting .225 as a unit (30th in MLB). It is also slugging a collective .370 (29th in MLB) with 154 total home runs (21st in MLB).Mize has pitched 12 innings, giving up one earned run on eight hits while striking out 10 against the Guardians this season.Tigers batting statsThe Tigers have hit 187 homers this season, which ranks 10th in the league.Hitters for Detroit have a combined .420 slugging percentage this season, which ranks 10th in MLB.The Tigers have a team batting average of .249 this season, which ranks 12th among MLB teams.Detroit has scored 729 runs this season, which ranks seventh in MLB.The Tigers have an OBP of .318 this season, which ranks 13th in MLB.Detroit is ranked 25th in strikeouts per game (8.8) among MLB offenses.Guardians stats and trendsGuardians betting recordsThe Guardians have been victorious in 37, or 45.1%, of the 82 contests they have been chosen as underdogs in this season.Cleveland has a mark of 20-17 in contests where oddsmakers favor it by +120 or worse on the moneyline.The Guardians have an implied victory probability of 45.5% according to the moneyline set for this matchup.Cleveland and its opponents have hit the over in 62 of its 147 games with a total set by oddsmakers this season.The Guardians have an against the spread mark of 76-71-0 in 147 games with a line this season.Joey Cantillo (Guardians probable starter)The Guardians are sending Cantillo (5-3) to the mound to make his 11th start of the season. He is 5-3 with a 3.36 ERA and 92 strikeouts through 80 1/3 innings pitched.In his last appearance on Tuesday, the lefty threw eight scoreless innings against the Kansas City Royals while surrendering four hits.The 25-year-old has an ERA of 3.36, with 10.3 strikeouts per nine innings in 31 games this season. Opponents are hitting .223 against him.Cantillo is trying to continue a second-game quality start streak in this game.Cantillo will aim to last five or more innings for his sixth straight appearance. He’s averaging 2.6 innings per outing.In 17 of his 31 total appearances this season he has not surrendered an earned run.He will take the mound against a Tigers offense that ranks 12th in the league with 1259 total hits (on a .249 batting average). The team also slugs a collective .420 (10th in the league) with 187 total home runs (10th in MLB play).Cantillo has a 0.00 ERA and a 0 WHIP against the Tigers this season in one inning pitched, allowing a .000 batting average over one appearance.Guardians batting statsThe Guardians rank 21st in MLB play with 154 home runs. They average 1.0 per game.This season, Cleveland is slugging .370, the second-lowest percentage in the majors.The Guardians have the worst batting average in the league (.225).Cleveland is the fourth-lowest scoring team in MLB play averaging 3.9 runs per game (580 total).The Guardians are 29th in MLB with a .296 on-base percentage.