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Spencer Steer and the Cincinnati Reds will play Alec Burleson and the St. Louis Cardinals at Busch Stadium on Tuesday at 7:45 p.m. ET, in the first game of a three-game series. The Cardinals have been listed as -106 moneyline underdogs in this matchup against the favored Reds (-113). Cincinnati is a 1.5-run favorite (at +144 odds). The over/under is 8 runs for the matchup.
Take a look at everything you need to know from a betting perspective on the Reds-Cardinals game, regarding the run line, moneyline and total, plus expert picks.
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Check out the best moments between the St. Louis Cardinals and the Milwaukee Brewers!
Reds vs. Cardinals Game Information & OddsWhen: Tuesday, September 16, 2025 at 7:45 p.m. ETWhere: Busch Stadium in St. Louis, MissouriHow to watch on TV: FDSMW and FDSOH Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Reds -113 -106 8 -114 -106 -1.5 +144 -173 Reds vs. Cardinals PredictionScore Prediction: Cardinals 6, Reds 5Total Prediction: Over 8 runsWin Probabilities: Reds 51%, Cardinals 49%Reds vs. Cardinals Betting InsightsThe Reds have entered the game as favorites 64 times this season and won 33, or 51.6%, of those games.Cincinnati is 31-29 this season when entering a game favored by -113 or more on the moneyline.The moneyline for this contest implies a 53.1% chance of a victory for the Reds.The Cardinals have been chosen as underdogs in 83 games this year and have walked away with the win 39 times (47%) in those games.St. Louis has a mark of 34-43 in contests where oddsmakers favor it by -106 or worse on the moneyline.Sportsbooks have implied with the moneyline set for this matchup that the Cardinals have a 51.5% chance of pulling out a win.Reds Recent Betting PerformanceThe Reds have a 1-2 record across the three games they were a moneyline favorite in their last 10 matchups.In their last 10 outings, the Reds and their opponents combined to go over the run total three times (all 10 of the games had set totals).The Reds have a 5-5-0 record against the spread over their past 10 games.Reds Recent Stats Stat Avg/Total Record 4-6 Runs Per Game 4 HR 13 ERA 5.17 K/9 8.7 Reds Player InsightsElly De La Cruz is the bat to watch in the Reds lineup, leading the team in batting average (.263), home runs (19), and RBI (82).De La Cruz’s home runs put him 80th in MLB, and he is 31st in RBI.TJ Friedl has 20 doubles, two triples, 12 home runs and 74 walks while batting .261.Friedl ranks 164th in home runs and 178th in RBI in the majors.Steer is hitting .237 with 20 doubles, two triples, 17 home runs and 45 walks.Austin Hays has 15 doubles, five triples, 15 home runs and 29 walks while hitting .265.Cardinals Recent Betting PerformanceIn seven games as underdogs over the last 10 matchups, the Cardinals have a record of 2-5.In their last 10 games with a total, the Cardinals and their opponents have failed to hit the over six times.The Cardinals have a record of 4-6-0 ATS over their last 10 games.Cardinals Recent Stats Stat Avg/Total Record 4-6 Runs Per Game 3.4 HR 6 ERA 4.10 K/9 7.8 Cardinals Player InsightsBurleson leads the Cardinals with a team-leading batting average of .281.Burleson is 100th in home runs and 95th in RBI among all hitters in the big leagues.Willson Contreras has hit 20 home runs with 79 runs batted in, leading the team in both categories.Contreras is 70th in home runs and 41st in RBI among all major league hitters this year.Brendan Donovan is batting .279 with 25 doubles, 10 home runs and 41 walks.Lars Nootbaar has 23 doubles, a triple, 13 home runs and 58 walks while hitting .240.Cardinals vs. Brewers Highlights | MLB on FOX
Check out the best moments between the St. Louis Cardinals and the Milwaukee Brewers!
FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.
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