The Houston Astros are set to face the Seattle Mariners to start the highly anticipated third game of their three-game series on September 21, 2025, at 7:10 pm ET/4:10 pm PT. The Mariners shut out the Astros 4-0 in the opening game of the current three-game series.

The Mariners rank higher at 11th with 4.73 runs per game, while the Astros average 4.23 runs per game, which places them in 24th spot. Seattle is in 20th place with a batting average of .244, while Houston is in ninth place with a .251 at the plate.

The Mariners have a little lead with a .320 on-base percentage, which places them in the tenth spot, just ahead of the Astros’ .317 on-base percentage, which ranks fourteenth. Seattle leads once more, finishing 10th with a .420 slugging percentage, followed by Houston in 16th place with a .398 slugging percentage.

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How to watch Houston Astros vs Seattle Mariners on TV & stream live online

National TV channel: ESPN

Streaming service: Fubo

To watch the entire MLB season, Fubo and DirecTV Stream are the two best streaming services for baseball fans. Both carry MLB.tv for out-of-market access to games and you can also check out our table below for information on regional sports networks and where to find them.

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TeamLocal NetworkStreaming ProvidersArizona DiamondbacksDBACKS.tvFubo, DirecTV StreamAtlanta BravesFanDuel Sorts Network SouthFubo, DirecTV StreamBaltimore OriolesMid-Atlantic Sports NetworkFubo, DirecTV StreamBoston Red SoxNew England Sports NetworkFubo, DirecTV Stream, NESN 360Chicago CubsMarquee Sports NetworkFubo, DirecTV StreamChicago White SoxNBC Sports ChicagoFubo, DirecTV StreamCincinnati RedsFanDuel Sports Network OhioFubo, DirecTV StreamCleveland GuardiansFanDuel Sports Network Great LakesFubo, DirecTV StreamColorado RockiesROCKIES.tvDirecTV StreamDetroit TigersFanDuel Sorts Network DetroitFubo, DirecTV Stream, FanDuel+Houston AstrosSpace City Home NetworkFubo, DirecTV StreamKansas City RoyalsFanDuel Sports Network Kansas CityFubo, DirecTV Stream, FanDuel+Los Angeles AngelsFanDuel Sports Network WestFubo, DirecTV StreamLos Angeles DodgersSportsNet Los AngelesDirecTV StreamMiami MarlinsFanDuel Sports Network FloridaFubo, DirecTV Stream, FanDuel+Milwaukee BrewersFanDuel Sports Network WisconsinFubo, DirecTV Stream, FanDuel+Minnesota TwinsFanDuel Sports Network NorthFubo, DirecTV StreamNew York MetsSportsNet New YorkFubo, DirecTV StreamNew York YankeesYES NetworkFubo, DirecTV StreamOakland AthleticsNBC Sports CaliforniaFubo, DirecTV StreamPhiladelphia PhilliesNBC Sports PhiladelphiaFuboPittsburgh PiratesSportsNet PittsburghFubo, DirecTV StreamSan Diego PadresPadres.TVFubo, DirecTV StreamSan Francisco GiantsNBC Sports Bay AreaFubo, DirecTV StreamSeattle MarinersROOT SportsFubo, DirecTV StreamSt Louis CardinalsFanDuel Sports Network MidwestFubo, DirecTV StreamTampa Bay RaysFanDuel Sports Network SunFubo, DirecTV Stream, FanDuel+Texas RangersFanDuel Sports Network SouthwestFubo, DirecTV StreamToronto Blue JaysSportnet (Canada)N/AWashington NationalsMid-Atlantic Sports NetworkFubo, DirecTV StreamHouston Astros vs Seattle Mariners: Date and First-Pitch Time

The Houston Astros and the Seattle Mariners will meet in an electrifying MLB game on September 21, 2025, at 7:10 pm ET/4:10 pm PT at Daikin Park in Houston, Texas.

DateSeptember 21, 2025First-Pitch Time7:10 pm ET/4:10 pm PTVenueDaikin ParkLocationHouston, TexasStreaming the game with a VPN

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Houston Astros vs Seattle Mariners team newsHouston Astros team news

Jose Altuve has contributed 74 RBIs, a batting average of .261, and 26 home runs.

Jeremy Pena is hitting .303 with a .361 on-base percentage and a .470 slugging percentage.

Christian Walker has a .233 batting average, 23 home runs, and 82 RBIs.

Houston Astros injury reportPlayerPositionInjuryInjury StatusYordan AlvarezLFLeft ankle sprainOut, 10-Day ILJosh HaderRPLeft shoulder strainOut, 15-Day ILSeattle Mariners team news

Cal Raleigh has 56 home runs, a .246 batting average, and 118 RBI.

Julio Rodríguez is hitting .269 with a .321 on-base percentage and a .479 slugging percentage.

Eduard Bazardo has a 5-0 record and a 2.36 ERA.

Seattle Mariners injury reportPlayerPositionInjuryInjury StatusJackson KowarRPRight shoulder impingementOut, 15-Day ILLogan EvansSPRight elbow inflammationOut, 15-Day ILHouston Astros and Seattle Mariners projected starting pitchersDateHouston AstrosSeattle MarinersSeptember 19, 2025Hunter BrownBryan WooSeptember 20, 2025Framber ValdezGeorge KirbySeptember 21, 2025Jason AlexanderLogan GilbertHouston Astros and Seattle Mariners head-to-head record

The series has been very well matched, with momentum going both ways in the last five meetings between the Houston Astros and the Seattle Mariners. The Mariners recently defeated the Astros 4-0 on September 20, 2025. They had previously won 7–6 in a thrilling game on July 20 and 6–1 on July 19.

However, the Astros have also had their explosive moments, such as their 5-3 victory on May 25 and their 11-3 victory on July 21.

The Mariners have demonstrated the ability to handle the Astros’ offense and win games that are controlled or low-scoring, but these results indicate that Houston’s bats can overwhelm Seattle when they are at their strongest. This pattern suggests that the outcome of the next game may depend on whether Seattle’s pitching silences them or if the Astros’ offense makes an early breakthrough.

DateResultsSep 20, 2025Mariners 4-0 AstrosJul 21, 2025Astros 11-3 MarinersJul 20, 2025Mariners 7-6 AstrosJul 19, 2025Mariners 6-1 AstrosMay 25, 2025Astros 5-3 MarinersMore MLB news and coverage