The Milwaukee Brewers (95-63) will visit the San Diego Padres (87-71), Wednesday at 4:10 p.m. ET, with the Brewers on a three-game losing streak.
The Brewers are favored (-130 on the moneyline to win) when they square off against the Padres (+109). The starting pitchers are Chad Patrick (3-8) for the Milwaukee Brewers, and Dylan Cease (8-12) for the San Diego Padres.
These squads meet again after the Padres’ 7-0 victory over the Brewers yesterday. Randy Vasquez (7.0 IP, 0 R, 1 H, 3 K) earned the win for the Padres. Luis Arraez went 2 for 3 with a home run and two RBIs to lead the team on offense. Bruce Zimmermann (6.0 IP, 5 R, 7 H, 1 K) was credited with the loss on the mound for the Brewers.
Ahead of the Brewers vs. Padres matchup, here’s everything you need to get ready for Wednesday’s baseball action, including viewing options.
Milwaukee Brewers vs. San Diego Padres odds, line and spread
MLB odds courtesy of BetMGM Sportsbook. Odds updated Wednesday at 6:16 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Favorite: Brewers (-130, bet $130 to win $100)Underdog: Padres (+109, bet $100 to win $109)Over/under: 8Brewers vs. Padres: Game time and live stream infoGame day: Wednesday, September 24, 2025Game time: 4:10 p.m. ETLocation: San Diego, CaliforniaStadium: PETCO ParkTV channel: MLB Network, SDPA, and FDSWILive stream: Watch LIVE with Fubo! (Regional restrictions may apply)
Watch Brewers vs. Padres on Fubo!
Brewers stats and trendsBrewers betting recordsThe Brewers have been favorites in 94 games this season and won 59 (62.8%) of those contests.This season Milwaukee has won 45 of its 63 games, or 71.4%, when favored by at least -130 on the moneyline.The implied probability of a win from the Brewers, based on the moneyline, is 56.5%.So far this season, Milwaukee and its opponents have hit the over in 76 of 158 games with a total.In 158 games with a spread this season, the Brewers are 87-71-0 ATS.Chad Patrick (Brewers probable starter)Patrick makes the start for the Brewers, his 23rd of the season. He is 3-8 with a 3.66 ERA and 119 strikeouts in 115 2/3 innings pitched.The right-hander’s last time out came on Saturday against the St. Louis Cardinals, when he went 4 1/3 innings, surrendering two earned runs while allowing five hits.The 27-year-old has a 3.66 ERA and 9.3 strikeouts per nine innings across 25 games this season, while allowing a batting average of .251 to his opponents.Patrick has five quality starts under his belt this year.Patrick enters this game with 14 outings of five or more innings pitched this year.In six of his appearances this season he did not allow an earned run.He will face a Padres offense that ranks 19th in the league with 677 runs while batting .252 as a squad. It has a collective .388 slugging percentage (22nd in MLB action) and has hit a total of 146 home runs (28th in MLB).Patrick has pitched six innings, giving up one earned run on four hits while striking out six against the Padres this season.Brewers batting statsThe Brewers rank 20th in Major League Baseball with 163 home runs.Fueled by 437 extra-base hits, Milwaukee ranks 12th in MLB with a .405 slugging percentage this season.The Brewers’ .259 batting average is among the best in baseball, ranking third in MLB.Milwaukee has scored 794 runs this season, which ranks third in MLB.The Brewers have the best on-base percentage (.333) in baseball this year.Milwaukee ranks fifth in MLB in strikeouts per game with an average of 7.8 whiffs per contest.Padres stats and trendsPadres betting recordsThe Padres have won in 35, or 50.7%, of the 69 contests they have been named as odds-on underdogs this year.This season, San Diego has come away with a win 21 times in 46 chances when named as an underdog of at least +109 or longer on the moneyline.The Padres have an implied victory probability of 47.8% according to the moneyline set by oddsmakers for this matchup.San Diego and its opponents have hit the over in 67 of its 158 games with a total set by oddsmakers this season.In 158 games with a line this season, the Padres have a mark of 85-73-0 against the spread.Dylan Cease (Padres probable starter)The Padres are sending Cease (8-12) to the mound for his 32nd start of the season. He is 8-12 with a 4.64 ERA and 207 strikeouts over 163 2/3 innings pitched.In his most recent time out on Friday, the right-hander went six innings against the Chicago White Sox, allowing four earned runs while surrendering four hits.In 31 games this season, the 29-year-old has put up an ERA of 4.64, with 11.4 strikeouts per nine innings. Opponents are hitting .237 against him.Cease has eight quality starts under his belt this year.Cease is seeking his fourth straight appearance lasting five or more innings. He averages 5.3 innings per start.He has made three appearances this season in which he did not give up an earned run.He will face a Brewers offense that ranks third in the league with 794 total runs scored while batting .259 as a squad. His opponent has a collective .405 slugging percentage (12th in MLB action) and has hit a total of 163 home runs (20th in the league).Among pitchers who qualify in MLB play this season, the 29-year-old ranks 43rd in ERA (4.64), 39th in WHIP (1.319), and first in K/9 (11.4).Padres batting statsThe Padres are third-worst in MLB action with 146 home runs.So far this season, San Diego is 22nd in baseball, slugging .388.The Padres rank seventh in MLB with a .252 batting average.The offense for San Diego is the No. 19 offense in baseball, scoring 4.3 runs per game (677 total runs).The Padres rank 10th in the majors with an on-base percentage of .320.