The Colorado Rockies (43-114) and the Seattle Mariners (88-69) play the middle contest of a 3-game interleague series Wednesday at T-Mobile Park in Seattle, Washington. First pitch is scheduled for 9:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Rockies vs. Mariners odds and make our expert MLB picks and predictions for the best bets.

Season series: Mariners lead 1-0

The Mariners (-295) and their side bettors sweated out a 4-3 victory in Tuesday’s series opener, but eventually Seattle won and clinched a postseason berth. 1B Josh Naylor, a key addition at the non-waiver trade deadline, had a 2-out, bases-clearing double in the eighth inning to propel the M’s to a victory.

Seattle has 15 wins in the past 16 outings, and it can win the AL West title with a victory Wednesday. It was anything but dominant Tuesday, though, and the M’s trailed 3-1 after 7 innings, while compiling just 3 hits in the win. The Mariners are 24-6 in 30 games at home since the All-Star break, the best record in the majors in that span.

In Tuesday’s game, Rockies RHP McCade Brown struck out 10 batters, becoming just the second Colorado pitcher this season to go for 10 or more strikeouts.

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Rockies at Mariners projected starters

RHP Tanner Gordon vs. RHP Luis Castillo

Gordon (6-7, 6.00 ERA) makes his 15th start. He has a 1.46 WHIP, 2.1 BB/9 and 7.4 K/9 through 72 innings.

Last start: Loss, 6 IP, 3 ER (4 R), 5 H (2 HR), 1 BB, 4 K in 9-7 home defeat vs. Miami Marlins ThursdayLast 7 games: 4-2, 3.96 ERA (38 2/3 IP, 17 ER), 1.09 WHIP, 8.6 K/92025 road stats: 2-3, 7.40 ERA (24 1/3 IP, 20 ER), 1.64 WHIP, 5 HR, 6 BB, 23 K in 5 startsHas never faced Mariners

Castillo (10-8, 3.63 ERA) makes his 32nd start. He has a 1.23 WHIP, 2.4 BB/9 and 7.9 K/9 through 173 1/3 innings.

Last start: Win, 6 IP, 0 ER, 3 H, 0 BB, 3 K in 2-0 victory at Kansas City Royals ThursdayLast 7 starts: 2-2, 5.40 ERA (35 IP, 21 ER), 1.40 WHIP, 8.2 K/92025 home stats: 4-4, 2.71 ERA (93 IP, 28 ER), 1.03 WHIP, 11 HR, 8.5 K/9 in 16 startsCareer vs. Rockies: 2-3, 5.72 ERA (28 1/3 IP, 18 ER), 1.31 WHIP, 5 HR, 11.1 K/9 in 5 startsRockies at Mariners odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:20 p.m. ET.

Moneyline (ML): Rockies +240 (bet $100 to win $240) | Mariners -300 (bet $300 to win $100)Run line (RL)/Against the spread (ATS): Rockies +1.5 (+115) | Mariners -1.5 (-140)Over/Under (O/U): 7.5 (O: -110 | U: -110)

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Rockies at Mariners picks and predictionsPrediction

Mariners 7, Rockies 3

The Mariners (-300) are obviously a no-go straight up, as betting Seattle would cost you 3 times your potential return, and that’s way too much risk for not nearly enough reward.

PASS, and look to the run line instead.

The MARINERS -1.5 (-140) are the play on the run line, as they have it all in front of them Wednesday night. A victory can help Seattle secure a division crown, while the Rockies have nothing to play for.

Seattle has won 5 in a row, and 4 of those wins were by 2 or more runs. In their past 15 victories, the Mariners have won by 2 or more runs 12 times. So, if you like the M’s to win, you should like them to get the job done on the run line, too.

OVER 7.5 (-110) is a strong play in this interleague game.

The Over has cashed in 6 of the past 9 games for the Mariners, while going 7-5 in the past 12 games at home.

For the Rockies, while the Under has cashed in the past 3 outings, the Over is still 6-3 across the past 9 games. And, the total has gone high at a 3-3-1 clip in the past 7 on the road.

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