The San Francisco Giants and Colorado Rockies are scheduled to meet in MLB action at Oracle Park on Friday, starting at 10:15PM ET.

Trevor McDonald (0-0, 3.38 ERA) will get the ball for the Giants, while the Rockies have opted for Germán Márquez (3-15, 6.49 ERA).

Based on updated simulation results, Dimers’ advanced MLB model predicts the Giants as the most likely winner of today’s game.

For a closer look at Friday’s matchup, including best bets and picks, visit our interactive Rockies vs. Giants predictions page.

Giants vs. Rockies prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the outcome of Friday’s MLB matchup between the Rockies and Giants 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Giants a 65% chance of beating the Rockies.

According to our model, the Rockies (+1.5) have a 53% chance of covering the run line, while the 8.5-run over/under has a 55% chance of going over.

 

Rockies vs. Giants odds [9/26/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type
Rockies
Giants

Run Line
+1.5 (-106)
-1.5 (-110)

Moneyline
+198
-225

Total
o8.5 (-105)
u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Rockies vs. Giants picks and best bets

Our model’s strongest edge in today’s Rockies vs. Giants matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot’s best bets

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Rockies vs. Giants game-day updates and essential details

Friday’s MLB action between the Giants and Rockies at Oracle Park is scheduled to commence at 10:15PM ET.

Dimers’ comprehensive preview of Friday’s Rockies vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Rockies vs. Giants picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Giants, with a 65% win probability, will likely beat the Rockies on Friday.

AI and automation have enhanced this article to quickly deliver accurate Rockies vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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