On Saturday, the St. Louis Cardinals (78-82) are visiting the Chicago Cubs (90-70), at 2:20 p.m. ET, in the second game of a three-game set.
The Cardinals are road underdogs (+144) versus the Cubs (-172). The Chicago Cubs will hand the ball to Jameson Taillon (10-7, 3.78 ERA), who is looking for win No. 11 on the season, and the Cardinals will counter with Michael McGreevy (8-3, 4.35 ERA).
These teams meet again after the Cubs beat the Cardinals 12-1 yesterday. Colin Rea registered the win for the Cubs (5.2 IP, 0 R, 2 H, 7 K), and Michael Busch led the way offensively (2 for 3 with a double, a home run and two RBIs). Miles Mikolas (5.0 IP, 4 R, 4 H, 4 K) was credited with the loss for the Cardinals.
Get ready for the Cubs vs. Cardinals with everything you need to know about Saturday’s game, including viewing options.
Chicago Cubs vs. St. Louis Cardinals odds, line and spread
MLB odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 12:17 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Favorite: Cubs (-172, bet $172 to win $100)Underdog: Cardinals (+144, bet $100 to win $144)Over/under: 9Cubs vs. Cardinals: Game time and live stream infoGame day: Saturday, September 27, 2025Game time: 2:20 p.m. ETLocation: Chicago, IllinoisStadium: Wrigley FieldTV channel: MARQ and FDSMWLive stream: Watch LIVE with Fubo! (Regional restrictions may apply)
Watch Cubs vs. Cardinals on Fubo!
Cubs stats and trendsCubs betting recordsThis season, the Cubs have been favored 114 times and won 72, or 63.2%, of those games.Chicago is 25-10 this season when entering a game favored by -172 or more on the moneyline.The Cubs have a 63.2% chance to win this game based on the implied probability of the moneyline.Chicago’s games have gone over the total in 74 of its 160 chances.In 160 games with a spread this season, the Cubs are 75-85-0 ATS.Jameson Taillon (Cubs probable starter)Taillon (10-7) takes the mound for the Cubs in his 23rd start of the season. He has a 3.78 ERA in 123 2/3 innings pitched, with 90 strikeouts.The righty’s last appearance came on Sunday against the Cincinnati Reds, when he threw seven innings, surrendering one earned run while allowing five hits.In 22 games this season, the 33-year-old has a 3.78 ERA and 6.5 strikeouts per nine innings, while giving up a batting average of .228 to opposing hitters.Taillon is looking to extend a second-game quality start streak in this game.Taillon is aiming for his third straight outing lasting five or more innings. He averages 5.6 innings per appearance on the mound.In one of his 22 total appearances this season he has not surrendered an earned run.The opposing Cardinals offense has the 27th-ranked slugging percentage (.379) and ranks 29th in MLB play with 146 home runs. It has a collective .246 batting average, and is 18th in MLB with 1318 total hits and 18th in MLB play scoring 686 runs.Taillon has an 18.00 ERA and a 2.500 WHIP against the Cardinals this season in four innings pitched, allowing a .421 batting average over one appearance.Cubs batting statsThe Cubs have hit 218 homers this season, which ranks sixth in the league.Hitters for Chicago have a combined .429 slugging percentage this season, which ranks sixth in MLB.The Cubs rank 14th in MLB with a .249 team batting average.Chicago has scored 784 runs this season, which ranks fourth in MLB.The Cubs have an OBP of .321 this season, which ranks ninth in MLB.Chicago ranks sixth in MLB in strikeouts per game with an average of 7.9 whiffs per contest.Cardinals stats and trendsCardinals betting recordsThe Cardinals have been chosen as underdogs in 91 games this year and have walked away with the win 44 times (48.4%) in those games.St. Louis has a mark of 5-16 in contests where bookmakers favor it by +144 or worse on the moneyline.The Cardinals have an implied victory probability of 41% according to the moneyline set for this matchup.St. Louis’ games have gone over the total in 80 of its 159 opportunities.In 159 games with a line this season, the Cardinals have a mark of 81-78-0 against the spread.Michael McGreevy (Cardinals probable starter)McGreevy gets the start for the Cardinals, his 16th of the season. He is 8-3 with a 4.35 ERA and 55 strikeouts in 91 2/3 innings pitched.His last time out was on Tuesday against the San Francisco Giants, when the righty went five innings, surrendering five earned runs while allowing six hits.The 25-year-old has amassed an ERA of 4.35, with 5.4 strikeouts per nine innings in 16 games this season. Opposing batters have a .266 batting average against him.McGreevy has registered seven quality starts this season.McGreevy is aiming for his fourth straight appearance lasting five or more innings. He averages 5.7 frames per start.He has had three appearances this season that he kept his opponents to zero earned runs.He will face a Cubs offense that is hitting .249 as a unit (14th in the MLB). They are also slugging a collective .429 (sixth in the league) with 218 total home runs (sixth in MLB play).Head-to-head against the Cubs this season, McGreevy has pitched 10 2/3 innings, giving up five earned runs on 13 hits while striking out four.Cardinals batting statsThe Cardinals are second-worst in MLB play with 146 home runs.So far this season, St. Louis is slugging .379, the fourth-lowest percentage in baseball.The Cardinals have the 17th-ranked batting average in the majors (.246).Averaging 4.3 runs per game (686 total), St. Louis is the 18th-highest scoring team in MLB.The Cardinals are 16th in baseball with an on-base percentage of .315.