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The Chicago Cubs will face off against the San Diego Padres in their 2025 home opener at Wrigley Field Friday.

MORE: See Chicago Cubs full 2025 MLB schedule

First pitch is at 1:20 p.m.

We now know the starting lineup for both teams. Check them out below.

Starting lineups for Cubs home opener:Chicago CubsIan Happ, LFKyle Tucker, RFSeiya Suzuki, DHMichael Busch, 1BDansby Swanson , SSNico Hoerner, 2BPete Crow-Armstrong, CFMatt Shaw, 3BMiguel Amaya, CShota Imanaga, P

🗣️: CHICAGOOOO!

Watch live on the Marquee Sports Network App. pic.twitter.com/wVZe93IrcT

— Chicago Cubs (@Cubs) April 4, 2025

San Diego PadresFernando Tatis, Jr., RFLuis Arraez, 1BManny Machado, 3BXander Bogaerts, SSJackson Merrill, CFYuli Gurriel, DHJake Cronenworth, 2BBrandon Lockridge, LFMartin Maldonado, C
Randy Vasquez, P

Good morning from Chicago! pic.twitter.com/0adtoDgpyE

— San Diego Padres (@Padres) April 4, 2025

This is the first in at three-game series against the Padres at home for the Cubs. After that, they take on the Texas Rangers at Wrigley for another three games. 

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