We’ve got another winner-take-all contest in the 2025 MLB playoffs, with the Chicago Cubs heading north to face the Milwaukee Brewers in Game 5 of the NLDS. The home team has won every game in this series, with Milwaukee taking the first two games and Chicago responding with wins in Game 3 and Game 4.

Those interested in MLB betting and looking for the latest Cubs vs. Brewers odds, predictions and picks should check out the SportsLine Projection Model, which simulates every game 10,000 times. The model enters the second week of the 2025 MLB playoffs a profitable 35-29 on top-rated MLB money line picks this season.

The Cubs will open the game with Drew Pomeranz (2-2, 2.17 ERA), though Shota Imanaga and Colin Rea will also likely be involved. Pomeranz’s strikeouts line at DraftKings Sportsbook is set at 0.5 (Over -258, Under +198). The Brewers are going with Trevor Megill (6-3, 2.49 ERA), who usually closes games. Megill’s strikeouts line is 1.5 (Over +161, Under -208).

Michael Busch, who has hit 38 home runs this season and four in these playoffs, is the +350 favorite at DraftKings to go yard in Game 5. His Cubs teammates Kyle Tucker (+435) and Seiya Suzuki (+453) are next in the odds ladder to hit a home run, followed by Brewers star Jackson Chourio (+456) and Andrew Vaughn (+473).

The Brewers are -143 favorites (wager $143 to win $100) on the money line in the latest SportsLine consensus odds for Game 5, with the Cubs priced at +120 (wager $100 to win $120). The total sits at 7.5. For the model’s latest projections and expert picks for Cubs vs. Brewers Game 5, visit SportsLine.

Check out the model’s best bets for Cubs vs. Brewers Game 5 on Saturday.

CHICAGO CUBS at MILWAUKEE BREWERS | 10/11 | 8:08 p.m. ET

Money line
Pick: Cubs +120
Chicago wins in 46% of simulations, bringing value at these odds

Run line
Pick: Cubs +1.5 (-176)
Chicago covers in 68% of simulations

Over/Under
Pick: Over 7.5
The Over hits in 59.2% of simulations

Projected score: Brewers 4.4, Cubs 4.3