The Guardians are -118 favorites vs the Cardinals

Guardians vs Cardinals Over / Under today: 8 Runs

Guardians / Cardinals TV Channel: GDTV | CATV

The Cleveland Guardians (-118) visit Busch Stadium to take on the St. Louis Cardinals (-102) on April 13, 2026. First pitch is scheduled for 7:45 pm in St. Louis, MO.

This season, the Guardians are 9-7 against the spread (ATS), while the Cardinals are 7-7 ATS.

Guardians vs Cardinals Starting Pitchers Today:

Guardians starting pitcher: Gavin Williams 1-1, 2.04 ERA

Cardinals starting pitcher: Matthew Liberatore 0-0, 3.38 ERA

Guardians vs. Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneylineGuardians-1.5 +145O 8 -110-118Cardinals +1.5 -180U 8 -110-102

Based on recent trends the model predicts the Cardinals will win Monday‘s MLB game with 52.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Guardians players for Monday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

Gavin Williams has hit the Hits Allowed Under in 20 of his last 25 games (+14.00 Units / 46% ROI)

Chase DeLauter has hit the Home Runs Over in 3 of his last 9 away games (+12.00 Units / 133% ROI)

Gavin Williams has hit the Walks Allowed Over in 17 of his last 25 games (+9.90 Units / 32% ROI)

Steven Kwan has hit the Hits Under in 14 of his last 25 games (+7.90 Units / 24% ROI)

Gavin Williams has hit the Strikeouts Over in his last 7 games (+7.45 Units / 90% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Monday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

Jordan Walker has hit the Home Runs Over in 6 of his last 8 games (+32.70 Units / 409% ROI)

Jordan Walker has hit the Runs Over in 13 of his last 20 games (+12.95 Units / 65% ROI)

Masyn Winn has hit the Total Bases Under in 18 of his last 25 games at home (+9.85 Units / 25% ROI)

Jordan Walker has hit the Hits Runs and RBIs Over in 14 of his last 20 games (+9.15 Units / 42% ROI)

Jordan Walker has hit the Hits Over in his last 8 games (+8.00 Units / 50% ROI)

Guardians Best Bets Today:

The Cleveland Guardians have hit the Moneyline in 33 of their last 50 games (+21.20 Units / 37% ROI)

The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 32 of their last 50 away games (+11.90 Units / 20% ROI)

The Cleveland Guardians have covered the Run Line in 28 of their last 45 games (+11.55 Units / 19% ROI)

The Cleveland Guardians have hit the Game Total Under in 25 of their last 40 games (+10.60 Units / 24% ROI)

The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 14 of their last 18 games (+9.10 Units / 42% ROI)

Cardinals Best Bets Today:

The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 24 of their last 40 games at home (+8.55 Units / 18% ROI)

The St. Louis Cardinals have hit the Team Total Under in 25 of their last 40 games at home (+8.45 Units / 18% ROI)

The St. Louis Cardinals have hit the Game Total Under in 23 of their last 40 games at home (+5.30 Units / 12% ROI)

The St. Louis Cardinals have hit the Moneyline in 12 of their last 20 games at home (+4.85 Units / 23% ROI)

The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 8 of their last 12 games at home (+3.00 Units / 19% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 9-7 against the Run Line (+0.15 Units / 0.68% ROI).

9-7 when betting on the Moneyline for +5.2 Units / 31.52% ROI

7-9 when betting on the total runs Over for -2.8 Units / -15.95% ROI

9-7 when betting on the total runs Under for +1.15 Units / 6.48% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 7-7 against the Run Line (-2.65 Units / -12.59% ROI).

8-7 when betting on the Moneyline for +2.05 Units / 13.23% ROI

8-6 when betting on the total runs Over for +1.5 Units / 9.26% ROI

6-8 when betting on the total runs Under for -3.1 Units / -18.34% ROI

Guardians Keys to the Game vs. the Cardinals

The Guardians are 35-4 (.875) when they’ve had 10 or more hits since the 2025 season — 2nd best in MLB; League Avg: .749.

The Guardians are just 0-7 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .024.

The Guardians were 33-4 (.868) when they had 10 or more hits in the 2025 season — 2nd best in MLB; League Avg: .743.

The Guardians were 24-2 (.923) when they had 5 or more XBH in the 2025 season — 2nd best in MLB; League Avg: .799.

Cardinals Keys to the Game vs. the Guardians

The Cardinals are just 0-7 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .024.

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals are just 8-12 (.400) when tied entering the 8th inning since the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals are 133-8 (.943) when leading entering the 8th inning since the 2024 season — 3rd best in MLB; League Avg: .904.

Guardians Hitting Stats & Trends

The Guardians batted just .186 in righty-righty matchups in the 2025 season — lowest in MLB.

Guardians hitters had an OPS of just .545 (690 PA’s) in righty-righty matchups in the 2025 season — lowest in MLB.

Guardians hitters slugged just .295 in righty-righty matchups in the 2025 season — lowest in MLB.

Guardians hitters have struck out in 32% of their PA’s in righty-righty matchups since the 2025 season — highest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters had an OPS of just .941 (1,172 PA’s) when the pitcher was behind in the count in the 2025 season — 2nd lowest in MLB.

Cardinals hitters slugged just .489 when the pitcher was behind in the count in the 2025 season — 2nd lowest in MLB.

Cardinals hitters are slugging just .484 with the pitcher behind in the count since the 2025 season — lowest in MLB.

The Cardinals are batting just .157 with two outs this season — lowest in MLB.

Guardians Pitching Stats & Trends

Opponents had a chase percentage of just 26% against the Guardians pitchers in the 2025 season — lowest in MLB.

Guardians pitchers have an ERA of 2.51 (498.1 IP) against division opponents since the 2025 season — best in MLB.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

Guardians pitchers had an ERA of 3.72 (706.0 IP) on the road in the 2025 season — tied for best in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 15% this season — lowest in MLB.

Opponents have a miss rate of just 19% against Cardinals pitchers this season — lowest in MLB.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2025 season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 32% with two-strikes this season — lowest in MLB.

More MLB Reading:

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