Odds updated as of 1:11 a.m.

The MLB slate on Wednesday includes the New York Mets facing the Minnesota Twins.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

New York Mets (7-16) vs. Minnesota Twins (12-11)Date: Wednesday, April 22, 2026Time: 7:10 p.m. ETVenue: Citi Field — Queens, New YorkCoverage: SNY and Twins.TVMets vs Twins Odds & MoneylineAll MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.Moneyline: NYM: (-158) | MIN: (+134)Spread: NYM: -1.5 (+140) | MIN: +1.5 (-170)Total: 8 — Over: (-106) | Under: (-114)Mets vs Twins Probable Starting Pitchers

Probable Pitchers: Clay Holmes (Mets) – 2-2, 1.96 ERA vs TBA (Twins)

The Mets will give the ball to Clay Holmes (2-2), while the Twins’ starting pitcher has not yet been announced. Holmes’ team is 2-2-0 against the spread this season in his starts. Holmes’ team is 1-1 this season when he starts and they’re favored on the moneyline.

Mets vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mets win (61.7%)

Looking at the moneyline for Twins-Mets, Minnesota is the underdog at +134, and New York is -158 playing at home.The Mets are hosting the Twins and are favored by 1.5 runs (+140 to cover) on the runline. Minnesota is -170 to cover.The over/under for Mets-Twins on April 22 is 8. The over is -106, and the under is -114.

Bet on New York Mets vs. Minnesota Twins on FanDuel today!

Mets vs Twins Betting TrendsThe Mets have won in five, or 33.3%, of the 15 contests they have been named as odds-on favorites in this year.New York has a record of 1-6 in contests when bookmakers favor them by -158 or more on the moneyline.The Mets and their opponents have gone over the total this season in 10 of their 23 opportunities.The Mets are 8-15-0 against the spread in their 23 games that had a posted line this season.The Twins are 10-6 in games they were the underdog on the moneyline (winning 62.5% of those games).When playing as a moneyline underdog with odds of +134 or longer, Minnesota has a 4-1 record (winning 80% of its games).In the 23 games oddsmakers have set an over/under for the Twins, they have combined with opponents to go over the total 14 times (14-9-0).The Twins have a 13-10-0 record against the spread this season (covering 56.5% of the time).Mets Player LeadersFrancisco Lindor is batting .209 with two doubles, two triples, two home runs and 11 walks. He has an on-base percentage of .301 and a slugging percentage of .341.Among qualified hitters in the majors, he ranks 142nd in batting average, 127th in on-base percentage, and 131st in slugging.Luis Robert has two doubles, two home runs and 12 walks. He’s batting .243 and slugging .351 with an on-base percentage of .349.He ranks 97th in batting average, 67th in on-base percentage and 123rd in slugging in the major leagues.Francisco Alvarez leads his team in OBP (.357) and total hits (15) this season.Marcus Semien is batting .225 with a .292 OBP and eight RBI for New York this season.Twins Player LeadersJosh Bell has accumulated a team-best slugging percentage (.430) while pacing the Twins in hits (20). He’s batting .253 and with an on-base percentage of .348.Including all qualifying hitters in MLB, he ranks 79th in batting average, 69th in on-base percentage and 72nd in slugging percentage.Luke Keaschall is slugging .289 to lead his team. He has a batting average of .222 with an on-base percentage of .268.Including all qualifying hitters, he is 125th in batting average, 163rd in on-base percentage and 155th in slugging percentage.Ryan Jeffers is hitting .263 with two doubles, a triple, two home runs and 10 walks.Byron Buxton’s 20 hits and .430 slugging percentage are both team-highs.4/21/2026: 5-3 MIN (Favorite: Mets, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)4/16/2025: 4-3 MIN (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)4/15/2025: 6-3 MIN (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)4/14/2025: 5-1 NYM (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)7/31/2024: 8-3 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)7/30/2024: 2-0 NYM (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)7/29/2024: 15-2 NYM (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)9/10/2023: 2-0 NYM (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)9/9/2023: 8-4 MIN (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -146, Underdog Moneyline: +124)9/8/2023: 5-2 MIN (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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