JD Yonke
• Betting Analyst
7+ years betting experience
Updated:
Apr 22, 2026 , 08:56 AM ET
• 4 min read
Our Dodgers vs. Giants predictions think the value lies with San Francisco at home.
Photo By – Reuters Connect. Tyler Mahle on the mound during a recent start.
The Los Angeles Dodgers hope to break out of a funk as Shohei Ohtani takes the mound for Game 2 of their series against the San Francisco Giants.Â
Tony Vitello’s built some much-needed momentum with a series-opening victory, however, and his squad is laser-focused on this rivalry series as a turning point in the young season.
My Dodgers vs. Giants predictions and MLB picks are backing the underdog on Wednesday, April 22.
Who will win Dodgers vs Giants today: Giants (+186)
The odds indicate that this is supposed to be a squash match for the Los Angeles Dodgers.
Shohei Ohtani’s pristine 0.50 ERA stands in stark contrast to Tyler Mahle’s (7.23), so the market expects a bounce-back from L.A. after Tuesday’s 3-1 defeat.Â
Mahle’s due for positive regression, however, as he pitched to a 2.18 ERA across 16 starts a year ago and will benefit from the confines of pitcher-friendly Oracle Park.Â
Ohtani’s control (94 Location+) hasn’t come back to bite him yet, but that and his unsustainable .158 BABIP indicate his pretty ERA will creep up eventually.
COVERS INTEL: Tyler Mahle has found success against some of L.A.’s best hitters in the past. He’s held Ohtani, Kyle Tucker, and Max Muncy to six hits in 29 at-bats (.207 AVG) with 10 strikeouts.
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Dodgers vs Giants Over/Under pick: Under 7.5 (+108)
The first game of this series flew Under the total in a low-scoring 3-1 San Francisco Giants win, and a similar result could be in store during a chilly Wednesday night in San Francisco.Â
Temperatures in the high-50s for most of this contest will benefit both starting pitchers as well as the two Top-10 bullpens behind them (LAD 3.49 SIERA in relief; SFG 3.59).Â
L.A. is in a bit of a slump, dropping three of its last four games while missing Mookie Betts and Tommy Edman in the lineup. San Francisco, meanwhile, has yet to get the bats going against right-handed pitching (79 wRC+).
JD Yonke’s 2026 Transparency Record
ML/RL bets: 7-5, +3.08 units
Over/Under bets: 8-5, +2.74 units
Dodgers vs Giants odds
Moneyline: Dodgers -200 | Giants +190
Run line: Dodgers -1.5 (-120) | Giants +1.5 (-105)
Over/Under: Over 7.5 | Under 7.5
Dodgers vs Giants trend
The Dodgers have dropped three of their last four games, costing one-unit bettors a 5.75 unit loss. Find more MLB betting trends for Dodgers vs. Giants.
How to watch Dodgers vs Giants and game info
Location
Oracle Park, San Francisco, CA
Date
Wednesday, April 22, 2026
First pitch
9:45 p.m. ET
TV
Sportsnet-Los Angeles, NBCS-Bay Area
Dodgers starting pitcher
Shohei Ohtani
(2-0, 0.50 ERA)
Giants starting pitcher
Tyler Mahle
(0-3, 7.23 ERA)
Dodgers vs Giants latest injuries
Dodgers vs Giants weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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JD is a diehard college football fan with five years of experience writing betting and fantasy content for publications such as SportsGrid, Fantasy Points, Fantrax, and Devy Watch. An avid reader, he uses his inclination to look at things with an exhausting and in-depth, analytic viewpoint combined with a love for statistics and metrics to form a well-rounded handicapping approach.
e’s an integral member of the niche (but growing!) college fantasy football community, twice traveling to Canton, OH for the Fantasy Football Expo as a member of the CFF King’s Classic drafting squad. His specialization in college football DFS and prop betting taught him that there are exploitable markets to be found and that narrowing your focus is integral to being a profitable bettor.
A lifelong Californian who grew up playing baseball, basketball, football, and lacrosse, he’s glad to share a passionate love for sports with this wonderful community.
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