The Chicago White Sox are up against the Arizona Diamondbacks at Chase Field for Game 2 of the series on Wednesday night. First pitch is at 9:40 pm ET.

Arizona is a -152 favorite at FanDuel, and the total is set at 9. Both teams have been lighting up the scoreboard recently, and I think that continues here. Read on for reasons why I see this one going OVER the total.

White Sox vs. Diamondbacks Odds – April 22, 2026

Matchup Page: Chicago White Sox vs. Arizona Diamondbacks, Apr. 22, 9:40 pm ET

Chicago White Sox vs. Arizona Diamondbacks OddsTeamRun LineMoneylineTotalChicago White Sox+1.5 (-154)+128OVER 9 (-122)Arizona Diamondbacks-1.5 (+128)-152UNDER 9 (+100)

Odds as of April 22nd at FanDuel

White Sox vs. Diamondbacks Pick

The OVER trends in this matchup are hard to ignore. The total has gone OVER in seven of Chicago’s last eight games, five of their last five on the road, and five of Arizona’s last six games at home against the White Sox. That’s a lot of convergence on the same side.

Anthony Kay gets the start for Chicago and has pitched better than expected early on, carrying a 2.60 ERA and 1-0 record through four appearances. But the 1.50 WHIP tells a different story. He’s putting runners on. His career MLB numbers are a mess (5.59 ERA and 1.61 WHIP in 85.1 innings), and while his two years in Japan clearly improved him, this is a D-backs lineup that punishes contact pitchers. Arizona ranks seventh in slugging percentage at .399, and they’re 7-3 at home with guys like Corbin Carroll (.308), Ketel Marte (4 HR, 9 RBI), and Nolan Arenado (3 HR, 11 RBI) all producing.

Eduardo Rodriguez takes the mound for Arizona and has been sharp in limited action, posting a 1.96 ERA and 0.92 WHIP through his first three outings. That’s encouraging, but his last two full seasons tell a different story. He put up ERAs north of 5.00 in both 2024 and 2025 and carried a 1.54 WHIP last year across 29 starts. The White Sox hit .210 as a team, which is ugly, but they’re weirdly dangerous on the road with 18 home runs away from home, tied for third in MLB. Munetaka Murakami has been swinging a hot bat recently, and this lineup is capable of boom-or-bust outbursts against pitchers who aren’t at their sharpest.

Chase Field plays as a hitter’s park, and both starters have question marks in their profiles. The White Sox staff has a Pythagorean record of 7-14 and has allowed 109 runs, meaning they’ve been bleeding runs all month. I’ll take the OVER at -122.

White Sox vs. Diamondbacks Pick: OVER 9 Runs (-122)

White Sox vs. Diamondbacks Prop Bet

Anthony Kay UNDER 3.5 Strikeouts (-153 at DraftKings)

Kay isn’t a strikeout pitcher. His K/9 sits at 6.2 this season, and his 21.5% strikeout rate in Japan last year was actually lower than his career MLB mark. He’s a pitch-to-contact guy who relies on his cutter and changeup to generate weak contact, not whiffs.

That approach runs headfirst into the wrong matchup here. The Diamondbacks rank fourth in MLB in strikeout rate against left-handed pitching this season, meaning they put the ball in play more consistently than almost anyone against southpaws.

The last six starters to face Arizona have all gone UNDER their strikeout totals. Kay has already gone UNDER this number in two of his four starts, including a zero-strikeout outing on April 4. He doesn’t miss bats, and Arizona doesn’t chase. That combination keeps this prop under the number.

White Sox vs. Diamondbacks Betting TrendsThe OVER has cashed in 7 of the White Sox’s last 8 games.The OVER has hit in each of the White Sox’s last 5 road games.Arizona is 10-5 SU in its last 15 games and 5-2 SU in its last 7 home games against the White Sox.