The St. Louis Cardinals vs. Miami Marlins game is set for a first pitch at 12:10 p.m. ET on Wednesday, April 22, with Miami returning a 1.69x payout with a win, via PrizePicks. 

These National League squads play the rubber match of their three-game set at LoanDepot Park. Miami took care of St. Louis 5-3 in Monday’s series opener, but the Cardinals rebounded for a 5-3 triumph of their own on Tuesday.

Below, we’ll break down our Cardinals vs. Marlins prediction and picks for Wednesday’s MLB game, including the winner, over/under, and key player picks for PrizePicks.

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Cardinals vs. Marlins Prediction, Winner Payout, Over/Under – Wednesday, April 22

All five teams in the NL Central own winning records, while every other division has at least two teams with losing marks. The Cardinals (14-9) improved to 7-4 away from Busch Stadium on Tuesday, the second-best road record behind the Cincinnati Reds among division foes.

St. Louis seeks a 4-0 record in road series finales on Wednesday, averaging 6 runs in this situation. Meanwhile, Miami is 4-0 in the final game of a home set, scoring at least 5 runs in each of the past three finales at LoanDepot Park.

The Marlins (11-13) have played the second-most home games in baseball with 15, going 9-6. Miami cashed the under in its first three home contests against Colorado before an 8-2 over run in the next 10 outings.

Each of the first two matchups remained under the projected total of 8.5. St. Louis hit the over in seven of eight games before the pair of unders in the first two against Miami. 

Cardinals vs. Marlins Winner Payout, Over/Under – Wednesday, April 22

The Marlins enter Wednesday’s game as a home favorite against the Cardinals, returning a 1.69x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Cardinals vs. Marlins game on PrizePicks.

Spread: Miami Marlins -1.5 Over/Under: 8.5Game Winner Payout: Cardinals 2.04x | Marlins 1.69x

Play the Cardinals vs. Marlins winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Cardinals vs. Marlins Prediction on Over/Under – Wednesday, April 22

Here are the key game stats and trends behind our Cardinals vs. Marlins prediction on the over/under for Wednesday, April 22.

Lock in your Cardinals vs. Marlins prediction on PrizePicks before the line moves.

Miami sits 27th in xSLG at .374 through the first month, a drop from .411 last season.Cardinals SP Kyle Leahy owns subpar numbers in the form of xERA (5.68), xBA (.289), and K rate (15.1%).On the road, the Cardinals average 6.1 runs in 10 games started by right-handed pitchers.Miami’s strikeout rate at LoanDepot Park is 18.6%, the fifth-lowest in MLB for home teams.Marlins SS Xavier Edwards is riding a 6-game hitting streak, while 2B Otto Lopez picked up a hit in nine straight before going 0-for-5 last night.Cardinals vs. Marlins Player Picks, Stats for PrizePicks: 4/22/26

Here are top Cardinals vs. Marlins picks to target on PrizePicks for Wednesday, April 22. Today’s MLB picks for PrizePicks include P Janson Junk and RF Jordan Walker.

Marlins P Janson Junk vs. Cardinals Projection: 3.5 StrikeoutsJunk was held to just 3 strikeouts in his last start against the Milwaukee Brewers in 5.1 innings of work.The right-hander owns the second-lowest K/9 among Miami starters at 6.14, slightly ahead of ace Sandy Alcantara (5.86).In the last three games, the Cardinals have struck out 22 times against opposing starting pitchers.Junk is averaging 3.1 strikeouts in his last nine home starts since the 2025 All-Star break.

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Cardinals RF Jordan Walker vs. Marlins Projection: 5.5 Hitter Fantasy ScoreWalker had his 15-game hitting streak snapped in Tuesday’s win, going 0-for-4 with 2 strikeouts.In each of the prior four games, Walker posted at least 7 fantasy points, including 14 in Monday’s defeat.Walker’s offensive numbers rank towards the top of MLB, including a .636 xSLG, 23.2% barrel rate, and 58.9% hard-hit rate.During day games, the 23-year-old is hitting .316 with an OPS of 1.103. Walker hasn’t posted consecutive hitless games since early April.

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Make Cardinals vs. Marlins Picks on PrizePicks

The Marlins finish off their homestand against the Cardinals before traveling west in today’s getaway game. Will Miami and St. Louis finally have a high-scoring affair in Wednesday’s rubber match?

Don’t wait until lock — make your Cardinals vs. Marlins picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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