{"id":647145,"date":"2026-03-27T19:17:19","date_gmt":"2026-03-27T19:17:19","guid":{"rendered":"https:\/\/www.rawchili.com\/mlb\/647145\/"},"modified":"2026-03-27T19:17:19","modified_gmt":"2026-03-27T19:17:19","slug":"guardians-vs-mariners-prediction-odds-home-run-pick-for-tonights-mlb-game","status":"publish","type":"post","link":"https:\/\/www.rawchili.com\/mlb\/647145\/","title":{"rendered":"Guardians vs Mariners Prediction, Odds & Home Run Pick for Tonight’s MLB Game"},"content":{"rendered":"

Want to get more Covers content? Add us as a preferred source on your Google account here<\/a>.<\/p>\n

Reigning division champs collide again at T-Mobile Park as the Cleveland Guardians and Seattle Mariners lock horns \u2014 and it\u2019ll take some special hitting to top last night\u2019s home run blitz.<\/p>\n

These teams combined for six dingers in yesterday\u2019s season opener, with Cleveland picking up a 6-4 win, and my Guardians vs. Mariners predictions expect Jose Ramirez to lead the charge for the visitors in this rematch.<\/p>\n

Get the lowdown on this clash with my free\u00a0MLB picks<\/a>\u00a0for Friday, March 27.<\/p>\n

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Guardians vs Mariners predictionsGuardians vs Mariners best bet: Jose Ramirez Over 1.5 total bases (+140)<\/p>\n

If you\u2019re in the market for consistent production, look no further than Jose Ramirez<\/a>. His hit totals for the past four seasons read: 168, 172, 173, 168 \u2013 and there\u2019s no sign of decline for the wily veteran.<\/p>\n

Ramirez thumped a two-RBI double last night to turn the contest in the Cleveland Guardians<\/a> favor, and he\u2019s had success against Seattle Mariners<\/a> starter George Kirby<\/a> to the tune of a 6-for-12 record, with three doubles and a homer.<\/p>\n

When the Mariners go to the bullpen, it\u2019s worth noting that Ramirez also has a pair of hits against key relievers Gabe Speier and Andres Mu\u00f1oz.<\/p>\n

\"Covers\"<\/p>\n

Covers<\/p>\n

COVERS INTEL:<\/p>\n

George Kirby allowed a .264 average to left-handers last season, and that lines up nicely for the switch-hitting Ramirez and the other lefties in the Guardians lineup<\/p>\n

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Guardians vs Mariners same-game parlay (SGP)<\/p>\n

I\u2019ll take the run line with a pesky Cleveland offense that\u2019s packed with lefties, while trusting that Gavin Williams<\/a> \u2013 coming off a 3.06 ERA last year \u2013 can match Kirby. <\/p>\n

The visitors, and they\u2019ve got a real lead-off weapon in rookie Chase DeLauter, who marked his first regular season outing with two solo dingers last night.<\/p>\n

Then it\u2019s all about the elite hitting on show. Ramirez has already opened his RBI account for 2026, and Julio Rodriguez<\/a> can point to three career hits against Williams. J-Rod went 0-for-4 yesterday, but he finished with 174 hits and 95 RBIs in 2025.<\/p>\n

Guardians vs Mariners SGP<\/p>\n

Jose Ramirez Over 0.5 hits<\/p>\n

Julio Rodriguez Over 0.5 hits<\/p>\n

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Guardians vs Mariners home run pick: Cal Raleigh (+290)<\/p>\n

After a magical run last year, Cal Raleigh<\/a> didn\u2019t do himself any favors during the WBC, but look for his bat to do the talking tonight. Another regular season with 60 homers might be a stretch, but I\u2019m wagering on The Big Dumper to mash his first long ball of the year here.<\/p>\n

2026 Transparency record<\/p>\n

Best bets: 1-0, +0.65 units<\/p>\n

Guardians vs Mariners odds<\/p>\n

Moneyline: Cleveland +143 | Seattle -158<\/p>\n

Run line: Cleveland +1.5 (-150) | Seattle -1.5 (+130)<\/p>\n

Over\/Under: Over 7 (-105) | Under 7 (-115)<\/p>\n

Guardians vs Mariners trend<\/p>\n

The Over is 7-3 in the past 10 meetings between these teams. Find more MLB betting trends<\/a> for Guardians vs. Mariners.<\/p>\n

How to watch Guardians vs Mariners and game info<\/p>\n

Location<\/p>\n

T-Mobile Park, Seattle, WA<\/p>\n

Date<\/p>\n

Friday, March 27, 2026<\/p>\n

First pitch<\/p>\n

9:45 p.m. ET<\/p>\n

TV<\/p>\n

Apple TV<\/p>\n

Guardians starting pitcher<\/p>\n

Gavin Williams
(2025: 12-5, 3.06 ERA)<\/p>\n

Mariners starting pitcher<\/p>\n

George Kirby
(2025: 10-8, 4.21 ERA)<\/p>\n

Guardians vs Mariners latest injuriesGuardians vs Mariners weather<\/p>\n

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.<\/p>\n

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This article originally appeared on Covers.com<\/a>, read the full article here<\/a> and view our best betting sites<\/a> or check out our top sportsbook promos<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"Want to get more Covers content? Add us as a preferred source on your Google account here. Reigning…\n","protected":false},"author":2,"featured_media":647146,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2380],"tags":[5,3297,22912,135,51,2565,11216,2078,465,538,865,3992,4,619,65],"class_list":["post-647145","post","type-post","status-publish","format-standard","has-post-thumbnail","category-cleveland-guardians","tag-baseball","tag-cal-raleigh","tag-chase-delauter","tag-cleveland","tag-cleveland-guardians","tag-clevelandguardians","tag-gabe-speier","tag-gavin-williams","tag-george-kirby","tag-guardians","tag-jose-ramirez","tag-julio-rodriguez","tag-mlb","tag-seattle","tag-seattle-mariners"],"share_on_mastodon":{"url":"https:\/\/channels.im\/@mlb\/116302751880033541","error":""},"_links":{"self":[{"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/posts\/647145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/comments?post=647145"}],"version-history":[{"count":0,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/posts\/647145\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/media\/647146"}],"wp:attachment":[{"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/media?parent=647145"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/categories?post=647145"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/tags?post=647145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}