March 27, 2026, 3:32 p.m. ET<\/p>\n
The Cleveland Guardians<\/a> (1-0) and the Seattle Mariners<\/a> (0-1) meet Friday at T-Mobile Park in Seattle, Washington. First pitch is scheduled for 9:40 p.m. ET (Apple TV). Let’s analyze MLB odds around the Guardians vs. Mariners odds and make our expert MLB picks and predictions<\/a> for the best bets.<\/p>\n 2025 season series: Mariners won 4-2; Seattle swept a 3-game series at T-Mobile Park on June 13-15, outscoring the Guardians 17-5<\/p>\n Cleveland picked up a 6-4 victory on Opening Day on Thursday as moderate a underdog (+158) as the Over (6.5) easily cashed. OF Chase DeLauter was scorching the ball in the opener, going 3-for-5 with 2 solo home runs and 3 runs scored. 1B Rhys Hoskins resurfaced with a 3-for-3 night with a double, walk and run scored. 2B Brayan Rocchio was 2-for-3 with a double, run scored and 2 RBIs.<\/p>\n Seattle was outhit 12-6 with 2B Brendan Donovan and DH Dominic Canzone each collecting 2 hits. Donovan had a solo homer while Canzone posted a pair of solo blasts. OF Luke Raley ended up with a solo homer in 4 at-bats, too.<\/p>\n Watch MLB on Fubo!<\/a>Guardians at Mariners projected starters<\/p>\n RHP Gavin Williams vs. RHP George Kirby<\/p>\n Williams (12-5, 3.06 ERA) made 31 starts in 2025. He had a 1.27 WHIP, 4.5 BB\/9 and 9.3 K\/9 over 167 2\/3 innings.<\/p>\n 2025\/career vs. Mariners (2 starts): 1-0, 2.45 ERA (11 IP, 3 ER), 10 H (2 HR), 4 BB, 9 K2025 on road: 5-3, 3.12 ERA (80 2\/3 IP, 28 ER), 12 HR, 46 BB, 69 K in 15 starts<\/p>\n Kirby (10-8, 4.21 ERA) made 23 starts in 2025. He had a 1.19 WHIP, 2.1 BB\/9 and 9.8 K\/9 across 126 innings.<\/p>\n 2025 vs. Guardians (2 starts): 0-0, 3.00 ERA (12 IP, 4 ER), 11 H (3 HR), 3 BB, 11 KCareer vs. Guardians: 0-1, 5.11 ERA (24 2\/3 IP, 14 ER), 1.30 WHIP, 6.9 K\/9 in 5 starts2025 at home: 5-4, 3.38 ERA (66 2\/3 IP, 25 ER), 7 HR, 17 BB, 73 K in 12 startsGuardians at Mariners odds<\/p>\n Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub<\/a> for a full list. Lines last updated at 3:25 p.m. ET.<\/p>\n Moneyline (ML): Guardians +145 (bet $100 to win $145) | Mariners -175 (bet $175 to win $100)Run line (RL)\/Against the spread (ATS): Guardians +1.5 (-170) | Mariners -1.5 (+140)Over\/Under (O\/U): 7 (O: -105 | U: -115)<\/p>\n Slide into: BaseballHQ.com<\/a> for your fantasy baseball news. For decades, BHQ has been helping players just like you win! BHQ offers full-season subscriptions. Sign up today<\/a>!<\/p>\n Guardians at Mariners picks and predictionsPrediction<\/p>\n Guardians 4, Mariners 3<\/p>\n The GUARDIANS (+145) are a strong, moderately priced underdog. Cleveland won the opener against Seattle’s top pitcher, now the Guardians get to face Kirby, who has not had great success against them. While it’s a small sample size, back the numbers and take Cleveland to get a second win in as many nights.<\/p>\n If you’re a little hesitant to trust Cleveland’s patchwork lineup for a second straight game, GUARDIANS +1.5 (-170) is not priced out of line if you’d like a little bit of insurance.<\/p>\n The Guardians continually are picked to finish in the middle of the pack, or lower, but then they rise up and surprise on a regular basis.<\/p>\n AVOID.<\/p>\n I expect this score to come down right on the Total (7). After the Over cashed on Thursday in the opener, if I had a lean, it would be OVER 6.5 (-145) – ALTERNATE TOTAL LINE, but there is no sense paying up this early in the season just for some action. Let some trends develop before diving in full bore.<\/p>\n For more sports betting picks and tips, check out SportsbookWire.com<\/a> and BetFTW<\/a>.<\/p>\n Follow @danieledobish<\/a> on\u00a0Twitter\/X.\u00a0Follow SportsbookWire on Twitter\/X<\/a> and like us on Facebook<\/a>.<\/p>\n Our team of savvy editors independently handpicks all recommendations. If you purchase through our links, the USA TODAY Network may earn a commission. Prices were accurate at the time of publication but may change.<\/p>\n Gambling involves risk. 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