{"id":681056,"date":"2026-04-22T13:30:21","date_gmt":"2026-04-22T13:30:21","guid":{"rendered":"https:\/\/www.rawchili.com\/mlb\/681056\/"},"modified":"2026-04-22T13:30:21","modified_gmt":"2026-04-22T13:30:21","slug":"dodgers-vs-giants-prediction-picks-odds-for-todays-mlb-game","status":"publish","type":"post","link":"https:\/\/www.rawchili.com\/mlb\/681056\/","title":{"rendered":"Dodgers vs Giants Prediction, Picks & Odds for Today’s MLB Game"},"content":{"rendered":"

\"JD<\/p>\n

<\/p>\n

JD Yonke<\/a>
\n \u2022 Betting Analyst<\/p>\n

7+ years betting experience<\/p>\n

\n Updated:
\nApr 22, 2026 , 08:56 AM ET<\/p>\n

\u2022 4 min read<\/p>\n

Our Dodgers vs. Giants predictions think the value lies with San Francisco at home.<\/p>\n

\"Tyler<\/p>\n

Photo By – Reuters Connect. Tyler Mahle on the mound during a recent start.<\/p>\n

The Los Angeles Dodgers hope to break out of a funk as Shohei Ohtani takes the mound for Game 2 of their series against the San Francisco Giants.\u00a0<\/p>\n

Tony Vitello\u2019s built some much-needed momentum with a series-opening victory, however, and his squad is laser-focused on this rivalry series as a turning point in the young season.<\/p>\n

My Dodgers vs. Giants predictions and MLB picks<\/a> are backing the underdog on Wednesday, April 22.<\/p>\n

Who will win Dodgers vs Giants today: Giants (+186)<\/p>\n

The odds indicate that this is supposed to be a squash match for the Los Angeles Dodgers<\/a>.<\/p>\n

Shohei Ohtani<\/a>\u2019s pristine 0.50 ERA stands in stark contrast to Tyler Mahle<\/a>\u2019s (7.23), so the market expects a bounce-back from L.A. after Tuesday\u2019s 3-1 defeat.\u00a0<\/p>\n

Mahle\u2019s due for positive regression, however, as he pitched to a 2.18 ERA across 16 starts a year ago and will benefit from the confines of pitcher-friendly Oracle Park.\u00a0<\/p>\n

Ohtani\u2019s control (94 Location+) hasn\u2019t come back to bite him yet, but that and his unsustainable .158 BABIP indicate his pretty ERA will creep up eventually.<\/p>\n

\"Covers\" COVERS INTEL: Tyler Mahle has found success against some of L.A.\u2019s best hitters in the past. He\u2019s held Ohtani, Kyle Tucker, and Max Muncy to six hits in 29 at-bats (.207 AVG) with 10 strikeouts.<\/p>\n

Enjoying Covers content? Add us as a preferred source on your Google account \"Add<\/a>Dodgers vs Giants Over\/Under pick: Under 7.5 (+108)<\/p>\n

The first game of this series flew Under the total in a low-scoring 3-1 San Francisco Giants<\/a> win, and a similar result could be in store during a chilly Wednesday night in San Francisco.\u00a0<\/p>\n

Temperatures in the high-50s for most of this contest will benefit both starting pitchers as well as the two Top-10 bullpens behind them (LAD 3.49 SIERA in relief; SFG 3.59).\u00a0<\/p>\n

L.A. is in a bit of a slump, dropping three of its last four games while missing Mookie Betts and Tommy Edman in the lineup. San Francisco, meanwhile, has yet to get the bats going against right-handed pitching (79 wRC+).<\/p>\n

JD Yonke’s 2026 Transparency Record<\/p>\n

ML\/RL bets: 7-5, +3.08 units
\nOver\/Under bets: 8-5, +2.74 units<\/p>\n

Dodgers vs Giants odds<\/p>\n

Moneyline: Dodgers -200 | Giants +190
\nRun line: Dodgers -1.5 (-120) | Giants +1.5 (-105)
\nOver\/Under: Over 7.5 | Under 7.5<\/p>\n

Dodgers vs Giants trend<\/p>\n

The Dodgers have dropped three of their last four games, costing one-unit bettors a 5.75 unit loss. Find more\u00a0MLB betting trends<\/a> for Dodgers vs. Giants.<\/p>\n

How to watch Dodgers vs Giants and game info<\/p>\n

Location
\nOracle Park, San Francisco, CA<\/p>\n

Date
\nWednesday, April 22, 2026<\/p>\n

First pitch
\n9:45 p.m. ET<\/p>\n

TV
\nSportsnet-Los Angeles, NBCS-Bay Area<\/p>\n

Dodgers starting pitcher
\nShohei Ohtani
(2-0, 0.50 ERA)<\/p>\n

Giants starting pitcher
\nTyler Mahle
(0-3, 7.23 ERA)<\/p>\n

Dodgers vs Giants latest injuries<\/p>\n

Dodgers vs Giants weather<\/p>\n

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.<\/p>\n

Pages related to this topic<\/p>\n

\"JD<\/p>\n

JD is a diehard college football fan with five years of experience writing betting and fantasy content for publications such as SportsGrid, Fantasy Points, Fantrax, and Devy Watch. An avid reader, he uses his inclination to look at things with an exhausting and in-depth, analytic viewpoint combined with a love for statistics and metrics to form a well-rounded handicapping approach.<\/p>\n

e’s an integral member of the niche (but growing!) college fantasy football community, twice traveling to Canton, OH for the Fantasy Football Expo as a member of the CFF King’s Classic drafting squad. His specialization in college football DFS and prop betting taught him that there are exploitable markets to be found and that narrowing your focus is integral to being a profitable bettor.<\/p>\n

A lifelong Californian who grew up playing baseball, basketball, football, and lacrosse, he’s glad to share a passionate love for sports with this wonderful community.<\/p>\n

Read More<\/p>\n","protected":false},"excerpt":{"rendered":"JD Yonke \u2022 Betting Analyst 7+ years betting experience Updated: Apr 22, 2026 , 08:56 AM ET \u2022…\n","protected":false},"author":2,"featured_media":681057,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2408],"tags":[5,162,4,378,66,4343,4340,4344,4341,4342],"class_list":{"0":"post-681056","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-san-francisco-giants","8":"tag-baseball","9":"tag-giants","10":"tag-mlb","11":"tag-san-francisco","12":"tag-san-francisco-giants","13":"tag-sanfrancisco","14":"tag-sanfranciscogiants","15":"tag-sf","16":"tag-sf-giants","17":"tag-sfgiants"},"share_on_mastodon":{"url":"https:\/\/channels.im\/@mlb\/116448607803963841","error":""},"_links":{"self":[{"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/posts\/681056","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/comments?post=681056"}],"version-history":[{"count":0,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/posts\/681056\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/media\/681057"}],"wp:attachment":[{"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/media?parent=681056"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/categories?post=681056"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/tags?post=681056"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}