The St. Louis Cardinals vs. Miami Marlins game is set for a first pitch at 12:10 p.m. ET on Wednesday, April 22, with Miami returning a 1.69x payout with a win, via PrizePicks.\u00a0<\/p>\n
These National League<\/a> squads play the rubber match of their three-game set at LoanDepot Park. Miami took care of St. Louis 5-3 in Monday\u2019s series opener, but the Cardinals rebounded for a 5-3 triumph of their own on Tuesday.<\/p>\n Below, we’ll break down our Cardinals vs. Marlins prediction and picks for Wednesday’s MLB game, including the winner, over\/under, and key player picks for PrizePicks. <\/p>\n Make your picks<\/a> for Cardinals vs. Marlins on PrizePicks now.<\/p>\n {{mlb_offer_banner=”\/style-system\/ui-components-playbook”}}<\/p>\n Cardinals vs. Marlins Prediction, Winner\u00a0Payout, Over\/Under \u2013 Wednesday, April 22<\/p>\n All five teams in the NL Central own winning records, while every other division has at least two teams with losing marks. The Cardinals (14-9) improved to 7-4 away from Busch Stadium on Tuesday, the second-best road record behind the Cincinnati Reds among division foes.<\/p>\n St. Louis seeks a 4-0 record in road series finales on Wednesday, averaging 6 runs in this situation. Meanwhile, Miami is 4-0 in the final game of a home set, scoring at least 5 runs in each of the past three finales at LoanDepot Park.<\/p>\n The Marlins (11-13) have played the second-most home games in baseball with 15, going 9-6. Miami cashed the under in its first three home contests against Colorado before an 8-2 over run in the next 10 outings.<\/p>\n Each of the first two matchups remained under the projected total of 8.5. St. Louis hit the over in seven of eight games before the pair of unders in the first two against Miami.\u00a0<\/p>\n Cardinals vs. Marlins Winner Payout, Over\/Under \u2013 Wednesday, April 22<\/p>\n The Marlins enter Wednesday\u2019s game as a home favorite against the Cardinals, returning a 1.69x payout if they win outright, via PrizePicks Team Picks.<\/p>\n Here are the full payouts for the Cardinals vs. Marlins game on PrizePicks.<\/p>\n Spread: Miami Marlins -1.5 Over\/Under: 8.5Game Winner Payout: Cardinals 2.04x | Marlins 1.69x<\/p>\n Play the Cardinals vs. Marlins winner or over\/under<\/a> on PrizePicks Team Picks to earn real money \u2014 available in 35 states!<\/p>\n Team Picks data is live at the time of writing and is subject to change.<\/p>\n Cardinals vs. Marlins Prediction on Over\/Under \u2013 Wednesday, April 22<\/p>\n Here are the key game stats and trends behind our Cardinals vs. Marlins prediction on the over\/under for Wednesday, April 22.<\/p>\n Lock in your Cardinals vs. Marlins prediction on PrizePicks<\/a> before the line moves.<\/p>\n Miami sits 27th in xSLG at .374 through the first month, a drop from .411 last season.Cardinals SP Kyle Leahy owns subpar numbers in the form of xERA (5.68), xBA (.289), and K rate (15.1%).On the road, the Cardinals average 6.1 runs in 10 games started by right-handed pitchers.Miami\u2019s strikeout rate at LoanDepot Park is 18.6%, the fifth-lowest in MLB for home teams.Marlins SS Xavier Edwards is riding a 6-game hitting streak, while 2B Otto Lopez picked up a hit in nine straight before going 0-for-5 last night.Cardinals vs. Marlins Player Picks, Stats for PrizePicks:\u00a04\/22\/26<\/p>\n Here are top Cardinals vs. Marlins picks to target on PrizePicks for Wednesday, April 22. Today\u2019s MLB picks for PrizePicks include P Janson Junk and RF Jordan Walker<\/a>.<\/p>\n Marlins P Janson Junk vs. Cardinals Projection: 3.5 StrikeoutsJunk was held to just 3 strikeouts in his last start against the Milwaukee Brewers in 5.1 innings of work.The right-hander owns the second-lowest K\/9 among Miami starters at 6.14, slightly ahead of ace Sandy Alcantara<\/a> (5.86).In the last three games, the Cardinals have struck out 22 times against opposing starting pitchers.Junk is averaging 3.1 strikeouts in his last nine home starts since the 2025 All-Star break.<\/p>\n Add Janson Junk to your PrizePicks Lineup now.<\/a><\/p>\n {{mlb_offer_banner=”\/style-system\/ui-components-playbook”}}<\/p>\n Cardinals RF Jordan Walker vs. Marlins Projection: 5.5 Hitter Fantasy ScoreWalker had his 15-game hitting streak snapped in Tuesday\u2019s win, going 0-for-4 with 2 strikeouts.In each of the prior four games, Walker posted at least 7 fantasy points, including 14 in Monday\u2019s defeat.Walker\u2019s offensive numbers rank towards the top of MLB, including a .636 xSLG, 23.2% barrel rate, and 58.9% hard-hit rate.During day games, the 23-year-old is hitting .316 with an OPS of 1.103. Walker hasn’t posted consecutive hitless games since early April.<\/p>\n Add Jordan Walker to your PrizePicks Lineup now.<\/a><\/p>\n Make Cardinals vs. Marlins Picks on PrizePicks<\/p>\n The Marlins finish off their homestand against the Cardinals before traveling west in today\u2019s getaway game. Will Miami and St. Louis finally have a high-scoring affair in Wednesday\u2019s rubber match?<\/p>\n Don\u2019t wait until lock \u2014 make your Cardinals vs. Marlins picks<\/a> on PrizePicks now and earn real money if you\u2019re right.<\/p>\n Pick players, predict More or Less on their stats, and cash in if you\u2019re right. With Team Picks<\/a>, you can make predictions on game winners, spreads, and over\/unders, now available in 35 states.<\/p>\n Stay locked in on Playbook for daily MLB predictions<\/a>, picks, and news every day all the way through the 2026 World Series.<\/p>\n Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d\/b\/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state. Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results. Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com\/predict-regulatory<\/a>. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.<\/p>\n","protected":false},"excerpt":{"rendered":"The St. Louis Cardinals vs. Miami Marlins game is set for a first pitch at 12:10 p.m. ET…\n","protected":false},"author":2,"featured_media":681079,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2395],"tags":[5,1816,778,58,4171,4],"class_list":{"0":"post-681078","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-miami-marlins","8":"tag-baseball","9":"tag-marlins","10":"tag-miami","11":"tag-miami-marlins","12":"tag-miamimarlins","13":"tag-mlb"},"share_on_mastodon":{"url":"https:\/\/channels.im\/@mlb\/116448759872990958","error":""},"_links":{"self":[{"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/posts\/681078","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/comments?post=681078"}],"version-history":[{"count":0,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/posts\/681078\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/media\/681079"}],"wp:attachment":[{"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/media?parent=681078"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/categories?post=681078"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/tags?post=681078"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}