May 16, 2026, 11:42 a.m. ET<\/p>\n
The San Diego Padres<\/a> (26-18) and Seattle Mariners<\/a> (22-24) play on Saturday in the second game of their 3-game series in Seattle, Washington. First pitch from T-Mobile Park is at 7:15 p.m. ET (FOX). Let’s analyze MLB odds around the Padres vs. Mariners odds and make our expert MLB picks and predictions<\/a> for the best bets.<\/p>\n Season series: Padres lead 4-0.<\/p>\n The Padres are 4-2 in their last 6 games and 2-2 on their current road trip. They took the series opener on Friday 2-0, as starter Randy Vasquez pitched 6 shutout innings and closer Mason Miller earned his 14th save of the year. It was the third time in 9 starts that Vasquez didn’t allow an earned run this season.<\/p>\n The Mariners got 6 strong innings from starter Emerson Hancock, who allowed just 1 run on 5 hits and a walk, striking out 6. They are 3-4 in their last 7 games and Friday was the opener of a 6-game homestand. They are 2-5 in their last 7 games at T-Mobile Park.<\/p>\n Watch MLB on Fubo!<\/a>Padres at Mariners projected starters<\/p>\n RHP Walker Buehler vs. RHP Logan Gilbert<\/p>\n Buehler (2-2, 5.20 ERA) makes his ninth start. He has a 1.35 WHIP, 3.0 BB\/9 and 7.7 K\/9 through 36 1\/3 innings.<\/p>\n Last start: No-decision, 6 IP, 2 ER, 3 H, 0 BB, 2 K in 3-2, 10-inning home win over the St. Louis Cardinals on SundayLast start vs. Mariners: Win, 5 IP, 2 ER, 5 H, 1 BB, 7 K in 5-2 win in San Diego on April 16Career vs. Mariners: 2-1, 6.39 ERA (25 1\/3 IP, 18 ER), 1.50 WHIP, 9.2 K\/9 in 5 starts2026 road splits: 1-1, 10.13 ERA (10 2\/3 IP, 12 ER), 2.25 WHIP, 9.3 K\/9 in 3 starts<\/p>\n Gilbert (2-3, 3.78 ERA) makes his 10th start. He has a 1.16 WHIP, 1.8 BB\/9 and 9.4 K\/9 through 50 innings.<\/p>\n Last start: No-decision, 6 IP, 0 ER, 1 H, 0 BB, 9 K in 2-1 road loss to Chicago White Sox on SundayCareer vs. Padres: 4-1, 1.69 ERA (32 IP, 6 ER), 0.84 WHIP, 8.7 K\/9 in 5 starts2026 home splits: 2-2, 4.91 ERA (33 IP, 18 ER), 1.33 WHIP, 9.3 K\/9 in 6 startsPadres at Mariners odds<\/p>\n Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub<\/a> for a full list. Lines last updated at 11:30 a.m. ET.<\/p>\n Moneyline (ML): Padres +140 (bet $100 to win $135) | Mariners -170 (bet $170 to win $100)Run line (RL)\/Against the spread (ATS): Padres +1.5 (-160) | Mariners -1.5 (+135)Over\/Under (O\/U): 7 (O: -120 | U: +100)<\/p>\n Slide into: BaseballHQ.com<\/a> for your fantasy baseball news. For decades, BHQ has been helping players just like you win! BHQ offers full-season subscriptions. Sign up today<\/a>!<\/p>\n Padres at Mariners picks and predictionsPrediction<\/p>\n Mariners 5, Padres 3<\/p>\n The Padres are 13-8 in away games this season while Seattle is 12-12 at home, having lost 5 of its last 7 there.<\/p>\n Buehler has allowed 4 earned runs in each of his 3 starts away from home this season, though the Padres are 2-1 in those starts. His last start was one of his best of the season, however (2 ER in 6 IP).<\/p>\n Gilbert has allowed 2 or fewer runs in 5 of his last 7 starts.<\/p>\n Expect the Mariners to bounce back, but the run line will give you better value today.<\/p>\n PASS.<\/p>\n Twelve of the Padres’ last 15 losses have been by multiple runs. Seattle’s last 5 wins and 7 of their last 8 have been by multiple runs.<\/p>\n BET MARINERS -1.5 (+135)<\/p>\n Five of the Mariners’ last 8 games have had totals of 7 or more. Four of Gilbert’s last 6 outings have had totals of 7 or more.<\/p>\n Six of Buehler’s last 7 starts have had 7 or more total runs.<\/p>\n BET OVER 7 (-120).<\/p>\n Betting odds calculator<\/a><\/p>\n For more sports betting picks and tips, check out SportsbookWire.com<\/a> and BetFTW<\/a>.<\/p>\n Follow SportsbookWire on Twitter\/X<\/a> and like us on Facebook<\/a>.<\/p>\n Our editors independently choose our recommendations. Some content is produced with paid support from a third party, however our editorial decisions remain independent. If you buy through our links, the USA TODAY Network may earn a commission. Prices and availability may change.<\/p>\n Gambling involves risk. 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