{"id":705962,"date":"2026-05-22T19:04:56","date_gmt":"2026-05-22T19:04:56","guid":{"rendered":"https:\/\/www.rawchili.com\/mlb\/705962\/"},"modified":"2026-05-22T19:04:56","modified_gmt":"2026-05-22T19:04:56","slug":"guardians-vs-phillies-prediction-picks-odds-for-todays-mlb-game","status":"publish","type":"post","link":"https:\/\/www.rawchili.com\/mlb\/705962\/","title":{"rendered":"Guardians vs Phillies Prediction, Picks & Odds for Today’s MLB Game"},"content":{"rendered":"

Want to get more Covers content? Add us as a preferred source on your Google account here<\/a>.<\/p>\n

The AL Central-leading Cleveland Guardians<\/a> roll into town on a six-game win streak, but Cristopher Sanchez<\/a> and the revived Philadelphia Phillies<\/a> are waiting for them.<\/p>\n

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Philadelphia has won six of its last seven series to get back to .500, and my Guardians vs. Phillies predictions back the hosts when they take on Cleveland starter Gavin Williams<\/a>, who\u2019s had some wobbly moments this season.<\/p>\n

Get the lowdown on this matchup with my free\u00a0MLB picks<\/a>\u00a0for Friday, May 22.<\/p>\n

Who will win Guardians vs Phillies today: Phillies (-175)<\/p>\n

For the Philadelphia Phillies<\/a>, the gloom is long gone. They\u2019re now\u00a016-6 since Don Mattingly took over, and I\u2019m trusting ace Cristopher Sanchez<\/a> to bring the heat in tonight\u2019s contest. <\/p>\n

Sanchez enters with a 1.82 ERA, and the Phillies have won each of his past four starts. In fact, the lefty hasn\u2019t given up a run this month \u2014 and he\u2019s only allowed more than two earned runs once this year.<\/p>\n

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Meanwhile, Gavin Williams<\/a> has posted a 5.12 ERA in his last five outings, and Alec Bohm<\/a> and Trea Turner<\/a> are a combined 6-for-9 against the Cleveland Guardians<\/a> righty.<\/p>\n

\"Covers\"<\/p>\n

Covers<\/p>\n

COVERS INTEL:<\/p>\n

Cristopher Sanchez has logged a 29.9% strikeout rate<\/a> through 10 starts this season \u2014 on pace for a career high \u2014 and he\u2019s racked up 30 Ks across his three outings so far in May.<\/p>\n

Guardians vs Phillies Over\/Under pick: Under 6.5 (-105)<\/p>\n

Sanchez\u2019s red-hot form has dragged down the O\/U line, but I\u2019m still taking the Under, which is 8-2 in the Phillies\u2019 last 10 games.<\/p>\n

Three of Sanchez\u2019s past four outings have delivered six total runs or fewer, and both these teams rank in the bottom third of the majors in batting average.<\/p>\n

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Though Williams is still searching for his best stuff, he only allowed two runs in six innings against Cincinnati<\/a> last weekend. <\/p>\n

Meanwhile, the Guardians\u2019 winning run hasn\u2019t really been fueled by offense. They\u2019ve scored three runs or fewer in six of their last nine contests.<\/p>\n

Tom Oldfield’s 2026 Transparency Record<\/p>\n

ML\/RL bets: 3-7, -5.30 units<\/p>\n

Over\/Under bets: 8-2, +5.16 units<\/p>\n

Guardians vs Phillies odds<\/p>\n

Moneyline: Guardians +145 | Phillies -175<\/p>\n

Run line: Guardians +1.5 (-150) | Phillies -1.5 (+125)<\/p>\n

Over\/Under: Over 6.5 (-1115) | Under 6.5 (-105)<\/p>\n

Guardians vs Phillies trend<\/p>\n

The Under is 6-1-1 in the last eight meetings between these teams.\u00a0Find more\u00a0MLB betting trends<\/a> for Guardians vs. Phillies.<\/p>\n

How to watch Guardians vs Phillies and game info<\/p>\n

Location<\/p>\n

Citizens Bank Park, Philadelphia<\/a>, PA<\/p>\n

Date<\/p>\n

Friday, May 22, 2026<\/p>\n

First pitch<\/p>\n

6:40 p.m. ET<\/p>\n

TV<\/p>\n

Guardians.TV, NBC Sports Philadelphia<\/p>\n

Guardians starting pitcher<\/p>\n

Gavin Williams
(6-3, 3.67 ERA)<\/p>\n

Phillies starting pitcher<\/p>\n

Cristopher Sanchez
(5-2, 1.82 ERA)<\/p>\n

Guardians vs Phillies latest injuriesGuardians vs Phillies weather<\/p>\n

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.<\/p>\n

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This article originally appeared on Covers.com<\/a>, read the full article here<\/a> and view our best betting sites<\/a> or check out our top sportsbook promos<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"Want to get more Covers content? Add us as a preferred source on your Google account here. The…\n","protected":false},"author":2,"featured_media":705963,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2380],"tags":[1651,5,535,135,51,2565,5143,2078,538,4,144,25,1713],"class_list":["post-705962","post","type-post","status-publish","format-standard","has-post-thumbnail","category-cleveland-guardians","tag-alec-bohm","tag-baseball","tag-cincinnati","tag-cleveland","tag-cleveland-guardians","tag-clevelandguardians","tag-cristopher-sanchez","tag-gavin-williams","tag-guardians","tag-mlb","tag-philadelphia","tag-philadelphia-phillies","tag-trea-turner"],"share_on_mastodon":{"url":"https:\/\/channels.im\/@mlb\/116619793172009583","error":""},"_links":{"self":[{"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/posts\/705962","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/comments?post=705962"}],"version-history":[{"count":0,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/posts\/705962\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/media\/705963"}],"wp:attachment":[{"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/media?parent=705962"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/categories?post=705962"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.rawchili.com\/mlb\/wp-json\/wp\/v2\/tags?post=705962"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}