The Boston Celtics will begin their 2025-26 season facing the Philadelphia 76ers on Wednesday, October 22, 2025 at 7:30 p.m. ET on NBCS-BOS and NBCS-PH.

The Celtics’ +747 scoring differential last season (outscoring opponents by 9.1 points per game) was a result of putting up 116.3 points per game (eighth in NBA) while giving up 107.2 per outing (second in league).

Celtics vs. 76ers: How to watch on TV or live stream

Watch this game on Fubo!

Celtics vs. 76ers odds and spread

NBA odds courtesy of BetMGM Sportsbook. Odds updated Monday at 8:24 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Spread Favorite: Celtics (-2.5)Moneyline: Celtics (-145), 76ers (+120)Total: 226.5 pointsCeltics players to watch (2024-25 stats)Jayson Tatum averaged 26.8 points, 8.7 boards and 6 assists last year, shooting 45.2% from the floor and 34.3% from beyond the arc, with 3.5 made 3-pointers per game (fourth in league).Derrick White averaged 16.4 points, 4.8 assists and 4.5 boards last year.Jaylen Brown averaged 22.2 points, 4.5 assists and 5.8 boards last year.Anfernee Simons averaged 19.3 points, 4.8 assists and 2.7 boards last year.Payton Pritchard averaged 14.3 points, 3.8 boards and 3.5 assists last year, shooting 47.2% from the field and 40.7% from downtown, with 3.2 made 3-pointers per contest (10th in league).

Watch this game on Fubo!