The Minnesota Timberwolves play the Portland Trail Blazers as 3.5-point favorites in the first game of the 2025-26 NBA season for both teams on Wednesday, October 22, 2025 at 10 p.m. ET on KUNP and FDSN.

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Listen to the game on Rip City Radio 620 Portland

Timberwolves vs. Trail Blazers Predictions for Wednesday

Our computer model for this game predicts a final tally of Timberwolves 115, Trail Blazers 109.

Moneyline Pick: Timberwolves (-166)
Total Pick: Over 221.5 (computer predicts 223.5 points)
Pick ATS: Timberwolves (-3.5)
Recent Timberwolves vs. Trail Blazers Matchups

Timberwolves 2024-25 Betting Trends

Minnesota was 39-43-0 against the spread last season.
The Timberwolves went 21-30 as 3.5-point favorites or greater last year.
Last year, 44 of Minnesota’s 82 games hit the over.
The Timberwolves went 40-23 in games they were favored on the moneyline last season (winning 63.5% of those games).
Minnesota had a record of 31-16 in games it played as a moneyline favorite with odds of -166 or shorter last year (66%).
Trail Blazers 2024-25 Betting Trends

Portland went 46-36-0 ATS last season.
Against the spread, as underdogs of 3.5 points or more, the Trail Blazers went 34-27 last season.
In Portland’s games last season, the combined scoring went over the point total 40 times.
The Trail Blazers were underdogs in 69 games last season and won 26 (37.7%) of those contests.
Last season, Portland won 19 of its 57 games, or 33.3%, when it was the underdog by at least +139 on the moneyline.

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Timberwolves vs. Trail Blazers Injury Report

Timberwolves

Timberwolves:

Leonard Miller: Out (Finger)

Trail Blazers

Trail Blazers:

Scoot Henderson: Out (Hamstring),

Damian Lillard: Out For Season (Achilles)

Timberwolves vs. Trail Blazers Game Time and TV Channel

Game day: Wednesday, October 22, 2025
Game time: 10 p.m. ET
TV channel: KUNP and FDSN
Location: Portland, Oregon
Arena: Moda Center
Live stream: Watch this game on Fubo (Regional restrictions may apply)

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