In the 2025-26 season opener for both teams, the Boston Celtics are favored by 2.5 points against the Philadelphia 76ers on Wednesday, October 22, 2025 at 7:30 p.m. ET. The matchup airs on NBCS-BOS and NBCS-PH. The over/under in the matchup is set at 226.5.
Boston went 61-21 last year and lost in the Conference Semifinals.
Celtics vs. 76ers betting information
NBA odds courtesy of BetMGM Sportsbook. Odds updated Tuesday at 1:24 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread: Boston -2.5Moneyline: Boston -145, Philadelphia +120Total: 226.5 pointsCeltics betting insightsThe Celtics put together a 39-43-0 ATS record last year.The Celtics were 38-39 ATS last season when playing as at least 2.5-point favorites.Celtics games went over the point total 37 out of 82 times last season.Celtics key playersJayson Tatum: 26.8 PTS, 8.7 REB, 6 AST, 1.1 STL, 45.2 FG%, 34.3 3PT% (250-for-728)Derrick White: 16.4 PTS, 1.1 BLK, 44.2 FG%, 38.4 3PT% (265-for-691)Jaylen Brown: 22.2 PTS, 1.2 STL, 46.3 FG%, 32.4 3PT% (116-for-358)Anfernee Simons: 19.3 PTS, 42.6 FG%, 36.3 3PT% (215-for-593)Payton Pritchard: 14.3 PTS, 47.2 FG%, 40.7 3PT% (255-for-626)Celtics vs. 76ers game info