The Philadelphia 76ers play the Boston Celtics at TD Garden on Wednesday, October 22, 2025. The game, the first of the 2025-26 season for both teams, begins at 7:30 p.m. ET on NBCS-BOS and NBCS-PH.
The 76ers’ -511 scoring differential last season (outscored by 6.2 points per game) was a result of scoring 109.6 points per game (26th in the NBA) while giving up 115.8 per contest (21st in the league).
76ers vs. Celtics: How to watch on TV or live stream
76ers vs. Celtics odds and spread
NBA odds courtesy of BetMGM Sportsbook. Odds updated Tuesday at 4:27 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Celtics (-2.5)Moneyline: Celtics (-145), 76ers (+120)Total: 226.5 points76ers players to watch (2024-25 stats)Tyrese Maxey averaged 26.3 points, 6.1 assists and 3.3 boards last season.Quentin Grimes averaged 14.6 points, 4.3 boards and 3.0 assists last year, shooting 46.7% from the floor and 38.5% from downtown, with 2.2 made 3-pointers per game.Kelly Oubre Jr.’s numbers last season were 15.1 points, 6.1 boards and 1.8 assists per game, shooting 47.0% from the field and 29.3% from beyond the arc, with 1.2 made 3-pointers per game.Paul George averaged 16.2 points, 5.3 boards and 4.3 assists last season. Defensively, he delivered 1.8 steals and 0.5 blocks.Trendon Watford averaged 10.5 points, 3.7 boards and 2.7 assists last year. Defensively, he put up 0.6 steals and 0.3 blocks.