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The SportsLine model has two NBA games in its Wednesday best bets at DraftKings, along with a college football pick. The model is backing two teams who have high expectations but look significantly different from last season, projecting the Mavericks to win and cover as 2.5-point favorites in Cooper Flagg’s debut, as well as the Celtics to win and cover in their season-opener without Jayson Tatum (Achilles) as 3.5-point favorites against the 76ers in the latest NBA odds at DraftKings Sportsbook. The model is also backing New Mexico State to cover as 1.5-point underdogs against Missouri State on CBS Sports Network in college football action in its Wednesday best bets at DraftKings. Claim the latest DraftKings promo code, where new users get $300 in bonus bets if your first $5 bet wins, plus 3 months of NBA League Pass free: 

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The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past seven seasons. The model enters the 2025-26 NBA season on a sizzling 160-118 roll on all top-rated NBA picks, returning nearly $4,000. It also went 24-11 (69%) on top-rated NBA against-the-spread picks last season. It is also a profitable 42-30 combined on money-line and over/under college football picks since the beginning of 2024. Anyone following its NBA betting advice or college football betting picks at sportsbooks and on betting apps could have seen huge returns.

Wednesday best bets at DraftKings SportsbookCeltics (-3.5) vs. 76ers (-110)Mavericks (-2.5) vs. Spurs (-115)New Mexico State (+1.5) vs. Missouri State (-118)

Combining the model’s three picks into a Wednesday parlay at DraftKings would result in a payout of +559 (risk $100 to win $559). Bet it at DraftKings here:

Celtics (-3.5) vs. 76ers (-110)

For the first time since he was drafted with the No. 3 overall pick in the 2017 NBA Draft, the Boston Celtics will be starting a season without Jayson Tatum, and the 2025-26 Celtics better get used to it. The six-time All-Star tore his Achilles in the Eastern Conference semifinals last year, meaning he’ll be out either all or nearly all of the regular season. But the Celtics, who have won more than 50 games in each of the last four seasons, are more than a one-man show, and with Derrick White and Payton Pritchard at guards under head coach Joe Mazzulla, the model predicts a strong start for Boston against a 76ers team that went 24-58 last season. Jaylen Brown (hamstring) is questionable for Wednesday, as he’ll take on the go-to role all season. Paul George (knee) is out for the 76ers. The model projects the Celtics to cover in 68% of simulations at home. Back the Celtics at DraftKings Sportsbook, where new users get $300 in bonus bets and 3 free months of NBA League Pass:

Mavericks (-2.5) vs. Spurs (-115)

The Cooper Flagg era is set to begin in Dallas on Wednesday as one of the most hyped No. 1 overall picks in recent NBA Draft history makes his debut. Flagg, a 6-foot-9 forward who can also play like a guard, is surrounded by plenty of talent as well, including Anthony Davis, D’Angelo Russell and Klay Thompson, so he won’t have as much pressure on him as many other high-profile No. 1 overall picks do early in their careers. The bouncing lottery balls went Dallas’ way after last season, when the Mavericks ended up with the top pick after just barely missing the postseason, going 39-43 and making the NBA Play-In Tournament. The Spurs, however, are coming off a 34-48 season, including 13-27 on the road. Dallas is home Wednesday, and the model projects the Mavericks to cover the spread in 67% of simulations. Back the Mavericks at DraftKings Sportsbook, where new users get $300 in bonus bets and 3 free months of NBA League Pass:

New Mexico State (+1.5) vs. Missouri State (-118)

The Aggies are underdogs for the third time in four home games this season, yet they are 3-0 on their home field this season. New Mexico State is 0-3 on the road, but its road struggles won’t matter on Wednesday. New Mexico State had no problems as a 1.5-point underdog in Conference USA play at home against Sam Houston, winning 37-10 on Oct. 2. Missouri State is coming off a 22-20 victory over a Middle Tennessee team that is winless in Conference USA play. New Mexico State senior quarterback Logan Fife is averaging 252.3 passing yards per game this season, and Missouri State ranks 110th in passing yards allowed this season. The model predicts New Mexico State to cover the spread in 70% of simulations on CBS Sports Network. Back New Mexico State at DraftKings Sportsbook, where new users get $300 in bonus bets and 3 free months of NBA League Pass:

Want more NBA picks and college football picks?

You’ve seen the model’s Wednesday best bets. Now, get against the spread, total and money-line picks for all games on Wednesday, including NBA, college football, NFL and NHL, all from the model that’s simulated every game 10,000 times.