The Los Angeles Lakers (6-2) are favored (-2.5) to extend a four-game winning streak when they host the San Antonio Spurs (5-1) at 10 p.m. ET on Wednesday, November 5, 2025 at Crypto.com Arena. The matchup airs on ESPN, SportsNet LA, and FDSSW.

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Lakers vs. Spurs Predictions for Wednesday

Our computer projection model for this game calls for a final result of Lakers 118, Spurs 113.

Moneyline Pick: Lakers (-144)
Total Pick: Over 230.5 (computer predicts 231.4 points)
Pick ATS: Lakers (-2.5)
Recent Lakers vs. Spurs Matchups

Lakers 2025-26 Betting Trends

Los Angeles has a 6-2-0 record against the spread this season.
The Lakers are a perfect 2-0 against the spread when favored by 2.5 points or more this season.
Out of Los Angeles’ six games with a set total, seven have hit the over (116.7%).
The Lakers have won both games they’ve played as favorites this season.
Los Angeles has played as a favorite of -144 or more once this season and won that game.
Spurs 2025-26 Betting Trends

San Antonio has covered the spread twice in six opportunities this season.
The Spurs are 1-0 against the spread so far when playing as at least 2.5-point underdogs.
In San Antonio’s six games with a set total, two have hit the over (33.3%).
The Spurs have been the moneyline underdog just one other time so far this season, a game they won.
San Antonio has played as a moneyline underdog of +121 or longer in only one game this season, which it won.

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Lakers vs. Spurs Injury Report

Lakers

Lakers:

Maxi Kleber: Day-To-Day (Oblique),

Austin Reaves: Day-To-Day (Groin),

Luka Doncic: Day-To-Day (Leg),

LeBron James: Out (Nerve),

Adou Thiero: Out (Knee),

Gabe Vincent: Out (Ankle)

Spurs

Spurs:

Dylan Harper: Out (Calf),

De’Aaron Fox: Out (Hamstring),

Kelly Olynyk: Questionable (Heel),

Luke Kornet: Out (Ankle),

Jeremy Sochan: Questionable (Wrist),

Lindy Waters III: Questionable (Eye)

Lakers vs. Spurs Game Time and TV Channel

Game day: Wednesday, November 5, 2025
Game time: 10 p.m. ET
TV channel: ESPN, SportsNet LA, and FDSSW
Location: Los Angeles, California
Arena: Crypto.com Arena
Live stream: Watch this game on Fubo (Regional restrictions may apply)

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