The Los Angeles Lakers (6-2) are 2.5-point favorites as they try to extend a four-game winning streak when they host the San Antonio Spurs (5-1) on Wednesday, November 5, 2025 at Crypto.com Arena. The matchup airs at 10 p.m. ET on ESPN, SportsNet LA, and FDSSW. The over/under for the matchup is 228.5.
Los Angeles won its previous game versus the Trail Blazers, 123-115, on Monday. Deandre Ayton was its top scorer with 29 points.
Lakers vs. Spurs betting information
NBA odds courtesy of BetMGM Sportsbook. Odds updated Wednesday at 1:24 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread: Los Angeles -2.5Moneyline: Los Angeles -140, San Antonio +115Total: 228.5 pointsLakers betting insightsSo far this season, the Lakers have put together a 6-2-0 record against the spread.The Lakers are 2-0 against the spread so far when playing as at least 2.5-point favorites.The teams have hit the over in seven of the Lakers’ six games with a set total.Lakers key playersAustin Reaves: 31.1 PTS, 9.3 AST, 1.4 STL, 48.9 FG%, 34.4 3PT% (21-for-61)Luka Dončić: 41.3 PTS, 11.5 REB, 8.3 AST, 1.3 STL, 54.5 FG%, 29.2 3PT% (14-for-48)Jake Laravia: 12.6 PTS, 1.6 STL, 58.5 FG%, 44.4 3PT% (12-for-27)Deandre Ayton: 16.9 PTS, 8.1 REB, 1.1 BLK, 65.1 FG%Rui Hachimura: 16.9 PTS, 59.3 FG%, 45.5 3PT% (15-for-33)Lakers vs. Spurs game infoGame day: Wednesday, November 5, 2025Game time: 10 p.m. ETLocation: Los Angeles, CaliforniaArena: Crypto.com ArenaTV channel: ESPNLive stream: Watch this game on Fubo