The Cleveland Cavaliers (4-3) square off against the Philadelphia 76ers (5-2) as 9.5-point favorites on Wednesday, November 5, 2025 at 7 p.m. ET on FDSOH and NBCS-PH. The matchup has an over/under of 234.5.

On Tuesday, in its last game, Philadelphia lost to the Bulls 113-111. With 39 points, Tyrese Maxey was its leading scorer.

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76ers vs. Cavaliers betting information

NBA odds courtesy of BetMGM Sportsbook. Odds updated Wednesday at 5:24 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Spread: Cleveland -9.5Moneyline: Cleveland -450, Philadelphia +340Total: 234.5 points76ers betting insightsThe 76ers have a 5-2-0 record against the spread this year.Five of the 76ers’ seven games with a set total have hit the over (71.4%).76ers key playersTyrese Maxey: 34.4 PTS, 8.4 AST, 1.1 STL, 1.1 BLK, 47.5 FG%, 48.5 3PT% (32-for-66)VJ Edgecombe: 19.1 PTS, 1.6 STL, 47.6 FG%, 43.9 3PT% (18-for-41)Kelly Oubre Jr.: 19.3 PTS, 1.3 STL, 53.9 FG%, 42.5 3PT% (17-for-40)Quentin Grimes: 17 PTS, 5 AST, 1.3 STL, 44 FG%, 40.4 3PT% (19-for-47)Joel Embiid: 17.8 PTS, 1.6 BLK, 42.3 FG%, 33.3 3PT% (8-for-24)76ers vs. Cavaliers game info

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