Mitchell, who made 16 of 27 shots from the field, also had nine rebounds and six assists. Jaylon Tyson added 27 points on 10-of-13 shooting and a team-high 11 rebounds. Evan Mobley and DeAndre Hunter each scored 13 for the Cavs.
Pascal Siakam had 26 points for Indiana, and Andrew Nembhard scored 21.
Garrison Mathews, who signed a second 10-day contract Monday with the Pacers, added 15 points — hitting all three of his attempts from three-point range. Jay Huff also scored 15.
The Cavaliers shot 51 per cent from the field while the Pacers shot 49 per cent. Cleveland had a 48-36 rebounding edge. Indiana had 14 turnovers, six more than Cleveland.
Cleveland led by 21 twice, the last time at 53-32 before settling for a 66-54 halftime lead. The Pacers’ only lead was 2-0. Hunter put the Cavaliers ahead for good at 5-2 with a three-pointer.
The teams shot nearly the same in the opening half as the Pacers were at 50 per cent and the Cavaliers at 49 percent. The difference was Cleveland had a 27-15 rebounding advantage and committed just three turnovers, while the Pacers had eight.
The Pacers trailed 99-90 after three quarters. The Cavaliers scored the first five points of the fourth quarter and retained a comfortable margin the rest of the game.
The Cavaliers were without Darius Garland, who sat out of the second of back-to-back games to manage his left toe injury. Lonzo Ball missed the game due to an illness.
Cavaliers: Host the Portland Trail Blazers on Wednesday night.
Pacers: Host the Denver Nuggets on Wednesday night.