The Portland Trail Blazers (9-13) and Detroit Pistons (17-5) meet Friday at Little Caesars Arena in Detroit, Michigan. Tip-off is set for 7:30 p.m. ET. Let’s analyze BetMGM Sportsbook’s NBA odds around the Trail Blazers vs. Pistons odds and make our expert NBA picks and predictions for the best bets.

2024-25 season series: Pistons swept 2-0

The Trail Blazers beat the Cleveland Cavaliers 122-110 Wednesday, covering as a 10-point road underdog with the Under (245) hitting. While Portland’s defense was the star of the show, G Deni Avdija dropped a team-high 27 points on 5-for-10 shooting. The Trail Blazers snapped a 3-game losing streak with the win. Despite the skid, Portland is 6-2 against the spread (ATS) over its last 8 games and 12-9-1 ATS on the season.

The Pistons lost to the Milwaukee Bucks 113-109 Wednesday. They failed to cover as a 4.5-point road favorite and the Under (228) cashed. Detroit was led by F Tobias Harris, who scored 20 points on 7-for-14 shooting. The Pistons, who have the best record in the Eastern Conference, are just 1-5 ATS across their last 6 contests and 13-9 ATS on the season.

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Trail Blazers at Pistons odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:50 a.m. ET.

Moneyline (ML): Trail Blazers +240 (bet $100 to win $240) | Pistons -300 (bet $300 to win $100)Against the spread: Trail Blazers +7.5 (-110) | Pistons -7.5 (-110)Over/Under (O/U): 235.5 (O: -105 | U: -115)Trail Blazers at Pistons key injuries

Trail Blazers

C Donovan Clingan (leg) questionableG Scoot Henderson (hamstring) outG Jrue Holiday (calf) outG Damian Lillard (Achilles) out for seasonF Kris Murray (hip) questionable

Pistons

F Duncan Robinson (ankle) questionable

For most recent updates: Official NBA injury report.

Trail Blazers at Pistons picks and predictionsPrediction

Pistons 119, Trail Blazers 113

PASS.

There’s no playable wager here. The Pistons (-300) should win, but they are too expensive to consider straight up.

BET TRAIL BLAZERS +7.5 (-110).

Portland has been on a strong run for bettors, primarily as an underdog. It has covered in 3 straight games overall and in its last 4 contests as an underdog. The Trail Blazers are also 4-1 ATS in their last 5 road games.

The Pistons have dealt with consistency issues lately, scoring 109 or fewer points in 3 of their last 4 games. They have failed to cover 5 straight as a favorite and are 2-3 ATS in their last 5 home games in that role.

Take TRAIL BLAZERS +7.5 (-110).

BET UNDER 235.5 (-115).

Detroit has gone Under in 3 of its last 4 home games, and its defense has impressed. The Pistons have held opponents to 113 points or fewer in 5 straight games at Little Caesars Arena.

The Trail Blazers are 2-4 O/U in their last 6 games, scoring 115 or fewer points in 4 of those outings. They have several key pieces sidelined, including Clingan, their starting center. That should impact their offense as well.

Take UNDER 235.5 (-115).

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