The San Antonio Spurs (16-7) are 4.5-point underdogs against the Los Angeles Lakers (17-6) at Crypto.com Arena on Wednesday, December 10, 2025. The game tips at 10 p.m. ET on Amazon Prime Video and SportsNet LA.

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Listen to the game on News Radio 1200 WOAI

Lakers vs. Spurs Predictions for Wednesday

Our computer projections model for this contest calls for a final score of Lakers 118, Spurs 117.

Moneyline Pick: Lakers (-186)
Total Pick: No Pick – Predicted Margin Negligible
Pick ATS: Spurs (+4.5)
Recent Lakers vs. Spurs Matchups

Lakers 2025-26 Betting Trends

Los Angeles has gone 14-9-0 ATS this season.
In games this season they were favored by 4.5 points or more, the Lakers have a 5-5 record against the spread.
A total of 16 of Los Angeles’ 23 games with a set total have hit the over (69.6%).
This season, the Lakers have won 10 out of the 12 games, or 83.3%, in which they’ve been favored.
This season, Los Angeles has won eight of its 10 games, or 80%, when favored by at least -186 on the moneyline.
Spurs 2025-26 Betting Trends

San Antonio is 10-11-2 ATS this season.
The Spurs are 3-2 against the spread when an underdog by 4.5 points or more this season.
A total of 13 of San Antonio’s 23 games with a set total have hit the over (56.5%).
The Spurs have a 6-3 record in games they were listed as the moneyline underdog (winning 66.7% of those games).
In games it has played as a moneyline underdog with odds of +154 or longer, San Antonio has gone 2-2 (50%).

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Lakers vs. Spurs Injury Report

Lakers

Lakers:

Marcus Smart: Day-To-Day (Back)

Spurs

Spurs:

Victor Wembanyama: Out (Calf),

Jordan McLaughlin: Day-To-Day (Hamstring)

Lakers vs. Spurs Game Time and TV Channel

Game day: Wednesday, December 10, 2025
Game time: 10 p.m. ET
TV channel: Amazon Prime Video and SportsNet LA
Location: Los Angeles, California
Arena: Crypto.com Arena

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