The Boston Celtics look to extend their winning streak to five games when they battle the Miami Heat in a key NBA Eastern Conference matchup on Friday night. Miami is coming off a 127-115 loss to the Atlanta Hawks on Tuesday, while Boston defeated the Houston Rockets 114-93 on Wednesday. The Heat (27-25), who lead the Southeast Division, are 11-15 on the road this season. The Celtics (33-18), who are tied with the New York Knicks for the Atlantic Division lead, are 16-8 on their home court. Miami’s Tyler Herro (toe) is not expected to play.

Tip-off from TD Garden in Boston is set for 7:30 p.m. ET. The Celtics lead the all-time series 88-54, and have won both meetings this season. Boston is a 6.5-point favorite in the latest Heat vs. Celtics odds from DraftKings Sportsbook, while the over/under for total points scored is 229.5. 

Before making any Heat vs. Celtics picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine’s model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 16 of the 2025-26 NBA season on a sizzling 38-16 roll on top-rated NBA spread picks dating back to last season. Anyone following could have seen HUGE returns!

The model has simulated Heat vs. Celtics 10,000 times and the results are in. We can tell you that the model is going Over on the point total, and it also says one side of the spread hits in nearly 70% of simulations!