Iowa State is into the second round.The Cyclones broke multiple school records en route to a dominant 108-74 victory over No. 15 seed Tennessee State in Friday’s round of 64. Now, the pressure ramps up.Iowa State takes on a Kentucky team riding high after winning a crazy first-round game against No. 10 seed Santa Clara, featuring a deep buzzer-beating 3-pointer by Kentucky to send the game to overtime.Here’s what to know about Sunday’s game.How to watch and stream Iowa State vs. Kentucky in the NCAA TournamentWhen: 1:45 p.m. CT, Sunday, March 22Where: Enterprise Center, St. LouisTV channel: KCCI/CBSLivestream: March Madness LiveTickets for Iowa State vs. Kentucky at the NCAA Tournament in St. LouisYou can find tickets for Sunday’s game here. A ticket will also get you into the Miami vs. Purdue game at 11:10 a.m.What to know about Kentucky basketballKentucky earned a No. 7 seed after going 21-13 in the regular season and SEC Tournament, including a 10-8 mark in SEC play. The Wildcats are in their second year under head coach Mark Pope, who won a national title as a Kentucky player in 1996.Otega Oweh is the clear leader for this year’s Kentucky team. A former Oklahoma Sooner, Oweh transferred to Kentucky ahead of his junior season in 2024-25 and has led the team in scoring both years since joining the squad.Oweh is a 6-foot-5 wing with the ability to light up the scoreboard quickly. He posted 35 points, 8 rebounds and 7 assists in Kentucky’s win over Santa Clara, including an incredible banked 3-pointer at the buzzer to send the game to overtime.Aside from Oweh, Kentucky has had a revolving door of contributing players. Eleven different players have made at least one start for Kentucky in 2025-26. Senior guard Denzel Aberdeen added 16 points in the win over Santa Clara, but the other three starters combined for just 8 points.Joshua Jefferson injury updateConsensus All-American Joshua Jefferson may not play Sunday after injuring his ankle in Friday’s win over Tennessee State.Jefferson left the game in the opening minutes of the contest after landing awkwardly on his ankle. KCCI’s Shannon Ehrhardt reported from St. Louis that Jefferson was on crutches and later in a walking boot. You can hear from Jefferson himself in the video below:Jefferson’s absence would be a big loss for the Cyclones. The big man entered the NCAA Tournament averaging 16.9 points, 7.6 rebounds and 4.9 assists per game.Iowa State vs. Kentucky basketball series historyThis will be the fourth meeting between Iowa State and Kentucky and the third to be played in the NCAA Tournament.Kentucky owns a 3-0 record. The last time these teams met was in 2012, when Anthony Davis led the No. 1 seed Wildcats past Royce White and Iowa State in the second round on their way to winning the national championship.March 17, 2012: Kentucky 87, Iowa State 71March 22, 1992: Kentucky 106, Iowa State 98Dec. 9, 1964: Kentucky 100, Iowa State 74Iowa State also has history with Kentucky coach Mark Pope, who spent five years coaching at BYU before taking the Kentucky job. Iowa State and BYU each won at home when the two teams played twice in 2023-24.

ST. LOUIS —

Iowa State is into the second round.

The Cyclones broke multiple school records en route to a dominant 108-74 victory over No. 15 seed Tennessee State in Friday’s round of 64. Now, the pressure ramps up.

Iowa State takes on a Kentucky team riding high after winning a crazy first-round game against No. 10 seed Santa Clara, featuring a deep buzzer-beating 3-pointer by Kentucky to send the game to overtime.

Here’s what to know about Sunday’s game.

How to watch and stream Iowa State vs. Kentucky in the NCAA TournamentWhen: 1:45 p.m. CT, Sunday, March 22Where: Enterprise Center, St. LouisTV channel: KCCI/CBSLivestream: March Madness Live

Tickets for Iowa State vs. Kentucky at the NCAA Tournament in St. Louis

You can find tickets for Sunday’s game here. A ticket will also get you into the Miami vs. Purdue game at 11:10 a.m.

What to know about Kentucky basketball

Kentucky earned a No. 7 seed after going 21-13 in the regular season and SEC Tournament, including a 10-8 mark in SEC play. The Wildcats are in their second year under head coach Mark Pope, who won a national title as a Kentucky player in 1996.

Otega Oweh is the clear leader for this year’s Kentucky team. A former Oklahoma Sooner, Oweh transferred to Kentucky ahead of his junior season in 2024-25 and has led the team in scoring both years since joining the squad.

Oweh is a 6-foot-5 wing with the ability to light up the scoreboard quickly. He posted 35 points, 8 rebounds and 7 assists in Kentucky’s win over Santa Clara, including an incredible banked 3-pointer at the buzzer to send the game to overtime.

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“OTEGA OWEH HAS JUST ETCHED HIS NAME INTO MARCH MADNESS LORE!”

Spero Dedes and Jim Spanarkel were ready for the madness during the thrilling finish of Santa Clara vs. Kentucky. pic.twitter.com/btsHjDPAau

— CBS Sports (@CBSSports) March 20, 2026

Aside from Oweh, Kentucky has had a revolving door of contributing players. Eleven different players have made at least one start for Kentucky in 2025-26. Senior guard Denzel Aberdeen added 16 points in the win over Santa Clara, but the other three starters combined for just 8 points.

Joshua Jefferson injury update

Consensus All-American Joshua Jefferson may not play Sunday after injuring his ankle in Friday’s win over Tennessee State.

Jefferson left the game in the opening minutes of the contest after landing awkwardly on his ankle. KCCI’s Shannon Ehrhardt reported from St. Louis that Jefferson was on crutches and later in a walking boot. You can hear from Jefferson himself in the video below:

Jefferson’s absence would be a big loss for the Cyclones. The big man entered the NCAA Tournament averaging 16.9 points, 7.6 rebounds and 4.9 assists per game.

Iowa State vs. Kentucky basketball series history

This will be the fourth meeting between Iowa State and Kentucky and the third to be played in the NCAA Tournament.

Kentucky owns a 3-0 record. The last time these teams met was in 2012, when Anthony Davis led the No. 1 seed Wildcats past Royce White and Iowa State in the second round on their way to winning the national championship.

March 17, 2012: Kentucky 87, Iowa State 71March 22, 1992: Kentucky 106, Iowa State 98Dec. 9, 1964: Kentucky 100, Iowa State 74

Iowa State also has history with Kentucky coach Mark Pope, who spent five years coaching at BYU before taking the Kentucky job. Iowa State and BYU each won at home when the two teams played twice in 2023-24.