March 25, 2026, 12:12 p.m. ET
The San Antonio Spurs (54-18) face the Memphis Grizzlies (24-27) at FedExForum Wednesday. Tip-off from Memphis, Tennessee, is set for 8 p.m. ET. Let’s analyze NBA odds around the Spurs vs. Grizzlies odds and make our expert NBA picks and predictions for the best bets.
Season series: Spurs lead 2-1
San Antonio dominated the Miami Heat 136-111 Monday while covering as a 3.5-point road favorite with the Over (244.5) cashing. C Victor Wembanyama led the Spurs with 26 points and 15 boards, while G Dylan Harper and F Keldon Johnson each put up 21 off the bench. The Spurs, 3 games behind the Western Conference-leading Oklahoma City Thunder, have won 6 straight, scoring over 130 in 3 of their last 4 wins.
Memphis was embarrassed 146-107 by the Atlanta Hawks Monday, failing to cover as a 13.5-point road underdog as the Over (239.5) was smashed. The Grizzlies allowed Atlanta to hit an insane 25-of-54 (46%) of their 3-pointers. The Grizzlies, who will not make the playoffs, turned the ball over 23 times and lost the rebounding battle 44-34.
The Grizzlies stunned thr Spurs 106-105 Jan. 5, covering as a 6-point home underdog with the Under (238.5) hitting. The Spurs shot an abysmal 37% from the floor and 30% from 3-point range in the loss.
Watch the NBA on Fubo!Spurs at Grizzlies odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:51 a.m. ET.
Moneyline (ML): Spurs -1600 (bet $1,600 to win $100) | Grizzlies +875 (bet $100 to win $875)Against the spread (ATS): Spurs -16.5 (-115) | Grizzlies +16.5 (-105)Over/Under (O/U): 232.5 (O: -115 | U: -105)Spurs at Grizzlies key injuries
Spurs
G De’Aaron Fox (back) outC Luke Kornet (knee) out
Grizzlies
F Santi Aldama (knee) outG Kentavious Caldwell-Pope (finger) outC Brandon Clarke (calf) outC Zach Edey (ankle) outG Ty Jerome (ankle) outG Ja Morant (elbow) outG Scotty Pippen Jr. (toe) outG/F Jaylen Wells (toe) out
For most recent updates: Official NBA injury report.
Spurs at Grizzlies picks and predictionsPrediction
Spurs 125, Grizzlies 104
PASS.
The Spurs are the much better team, so covering as -1600 favorites will be no problem here. However, no team favored so heavily on the ML is worth the risk of backing, so pass and bet on the spread and/or total instead.
LEAN SPURS -16.5 (-115).
San Antonio has covered the spread in each of its last 2 road games, while the Grizzlies have dropped back-to-back games ATS. The Spurs are also 39-32-2 ATS, while the Grizzlies sit at 33-37-1 ATS. The Spurs have also covered ATS in 3 of their last 4 matchups against the Grizzlies overall.
This is a LEAN because there is always risk when backing a team to cover by 17 points, especially given that the Spurs are just 5-5 ATS in their last 10 games.
BET UNDER 232.5 (-105).
The Under has hit in 4 of Memphis’ last 5 games and is 36-35 for the Grizzlies this season. For San Antonio, the Under is 3-3 in its last 6 games and 41-32. The Under is also 6-4 in the last 10 matchups between these squads, hitting in 4 of the last 5 matchups between these squads in Memphis.
Given San Antonio’s elite defense, the Under is nearly a lock here.
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