Updated May 14, 2026, 11:34 p.m. ET
The Detroit Pistons and Cleveland Cavaliers meet Friday for Game 6 of their second-round Eastern Conference playoff series at Rocket Arena in Cleveland, Ohio. Tip-off is scheduled for 7 p.m. ET (Prime Video). Let’s analyze NBA odds around the Pistons vs. Cavaliers odds and make our expert NBA picks and predictions for the best bets.
Best-of-7 series: Cavaliers lead 3-2; teams split 2-2 in regular season
The Cavaliers got a 117-113 road win in overtime in Wednesday’s Game 5 matchup, covering as +3.5-point underdogs with the Over (210.5) cashing. G James Harden led Cleveland with 30 points, hitting 11 of 14 free throw attempts, and also had 8 rebounds and 6 assists. G Donovan Mitchell put up 21 points and C Evan Mobley scored 19.
The Pistons have 3 straight games after opening the series with a 2-0 lead. G Cade Cunningham scored a team-high 39 points in Game 5, also pulling down 7 rebounds and dishing 9 assists. G Daniss Jenkins contributed 19 points. Detroit let a 9-point lead late in the fourth quarter slip through its fingers.
Watch the NBA on Fubo!Pistons at Cavaliers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 10:49 p.m. ET.
Moneyline (ML): Pistons +145 (bet 100 to win $145) | Cavaliers -175 (bet $175 to win $100)Against the spread (ATS): Pistons +3.5 (-102) | Cavaliers -3.5 (-118)Over/Under (O/U): 209.5 (O: -115 | U: -105)Pistons at Cavaliers key injuries
Pistons
G Caris Levert (heel) questionableG Duncan Robinson (back) questionable
Cavaliers
For most recent updates: Official NBA injury report.
Pistons at Cavaliers picks and predictionsPrediction
Cavaliers 111, Pistons 105
AVOID.
The Cavs have the momentum and home court advantage to close the series out, but you can’t completely count the Pistons out. Detroit overcame being down 3-1 to the Orlando Magic in the first round, and are the No. 1 seed in the East for a reason.
BET CAVALIERS -3.5 (-118).
Cleveland has played with determination over the past 3 games, and the Pistons have been disappointing as a whole throughout the playoffs. The Cavs are also perfect at home (6-0) during the postseason. C Jalen Duren has been very disappointing for Detroit in this series, not eclipsing more than 11 points in any game after averaging 19.5 during the regular season.
BET OVER 209.5 (-110).
These teams have hit the Over in each of their last 3 matchups, and have scored more than 210 points in all but 1 game of the series. The Pistons are 6-4 in favor of the Over during their last 10 games, and the Cavs are 7-3.
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