Cleveland Cavaliers vs Philadelphia 76ers Predictions
Best Bet
Cavaliers +3.5 @ -115
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Cavs Can Trouble Sixers
We’re confident of the Cavaliers staying close to the Sixers, with our prediction being that Cleveland will cover the spread. The +3.5 line looks generous at odds of -115.
Our Cavaliers vs Sixers betting guide covers our Best Bet, Player Props, Same Game Parlay and Correct Score Prediction. Explore the complete analysis behind each pick further down the page.
Cleveland Cavaliers vs Philadelphia 76ers Preview
The Cleveland Cavaliers take the floor against the Philadelphia 76ers in this NBA matchup.
Cleveland has retained its core of Donovan Mitchell, James Harden, Evan Mobley and Jarrett Allen heading into the 2026-27 season. The Cavaliers strengthened their roster by acquiring versatile forward Peyton Watson from Denver and signing Mario Hezonja, while Dennis Schröder, Keon Ellis and Max Strus departed.
The Cavs enter the 2026-27 season aiming to build on an impressive playoff run that saw Cleveland reach the Eastern Conference finals. Their previous campaign ended with a 4-0 series defeat to the eventual champion New York Knicks, including a heavy 130-93 home loss in Game 4 at Rocket Arena.
Donovan Mitchell led Cleveland with 31 points in that final encounter, while Evan Mobley contributed 15 and James Harden added 12. The Cavaliers will now look to go one step further after reaching the conference finals last season.
Philadelphia opened the new season with an impressive 106-100 road victory over the defending champion New York Knicks at Madison Square Garden. The Sixers overcame a four-point halftime deficit, outscoring New York 29-18 in the third quarter to take control of the contest.
Tyrese Maxey led Philadelphia with 28 points, five assists and three steals, while high-profile offseason acquisition Jaylen Brown impressed on his Sixers debut with 19 points, eight rebounds and six assists. Fellow newcomer LeBron James contributed 14 points, nine rebounds and seven assists in his first appearance for Philadelphia, while returning star Joel Embiid recorded a double-double of 13 points and 11 rebounds, along with six assists and three blocks.
H2H: Cavs Have Won Four Straight Against Sixers
Cleveland secured a convincing 115-101 home victory over Philadelphia at Rocket Arena in their most recent encounter. The Cavs have dominated this matchup lately, winning four consecutive games against the Sixers and seven of their last ten head-to-head meetings.
76ers
1
0
1
106
100
6
0-0
1-0
1-0
1-0
1-0
1W
Cavaliers
0
0
0
0
0
0
0-0
0-0
0-0
0-0
–
–
Cleveland Cavaliers – Last 10 Games
4 wins and 6 losses in the past 10 games. The Cavs are averaging 105.9 points, 38.3 rebounds, 21.7 assists, 7.7 steals and 5.3 blocks while shooting 44.6% from the field and 73.7% from the free-throw line. The opposition have averaged 111.6 points and 42.5 rebounds per contest.
Donovan Mitchell is averaging 28.3 points and 2.7 (31.4%) 3-pointers made. Evan Mobley averages 7.6 rebounds and James Harden 4.9 assists.
Philadelphia 76ers – Last 10 Games
The Sixers have won 4 and lost 6 of their last 10 contests. Averaging 103.8 points, 38.1 rebounds, 22.4 assists, 5.8 steals and 4.8 blocks per game while shooting 44.7% from the field and 80.7% from the free-throw line. Their opponents have an average of 112.3 points and 46.0 rebounds.
Tyrese Maxey is averaging 23.9 points and 5.3 assists, while Joel Embiid has an average of 6.2 rebounds and Paul George 3.2 (50.0%) 3-pointers made.
Confirmed Starting Lineups
Cleveland Cavaliers lineup: James Harden, Evan Mobley, Peyton Watson, Jarrett Allen, Donovan Mitchell.
Philadelphia 76ers lineup: Tyrese Maxey, Jaylen Brown, Joel Embiid, LeBron James, Valdez Edgecombe.
Best Bet
We’re making Cavaliers against the spread our pick for this NBA contest. The betting line is favorably set at +3.5 and you can secure -115 that this happens.
Key stats supporting our main match prediction:
The +3.5 line has been covered by Cavs in 11 of their last 20 games on the road.The -3.5 line hasn’t been covered by Sixers in 4 of their last 5 games.The -3.5 line hasn’t been covered by Sixers in 6 of their last 10 games.The -3.5 line hasn’t been covered by Sixers in 2 consecutive games at home.The -3.5 line hasn’t been covered by Sixers in 8 consecutive games against Cavs.
The handicappers at Sportsgambler.com stay on top of the latest injuries, while recent form also shapes our basketball picks. We combine this insight with up-to-date NBA stats for sharper predictions.
Cavs +3.5 Probability
According to the latest odds, our pick has a 53.5% chance of delivering a return. In the opinion of our cappers, there’s actually a probability of success closer to 60%. This bet can therefore be backed with confidence.
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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Oct 21, 20:02). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.
Published 20:02, 21 October 2026
Player Prop Picks
Joel Embiid (76ers) has scored an average of 17.25 points in the past 4 games. His Player Points might once again fall below the line, with this bet offering plenty of appeal and you can back -118.
Latest Joel Embiid Player Prop Odds
Jarrett Allen (Cavs) has scored an average of 16.8 points in the past 5 road games. We are therefore going to choose a Player Points prop bet at odds of -128 which will hopefully see this him cover the line.
Latest Jarrett Allen Player Prop Odds
Points
Rebounds
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Correct Score Prediction
We’re expecting this to be a close contest and we’ll take the Cavaliers to win 117-115. This is available at massive odds for those that want to have a speculative wager.
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Cleveland Cavaliers vs Philadelphia 76ers Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
Latest Moneyline Odds Suggest Sixers Victory
With the sportsbooks giving them a 61% probability of winning this NBA game, Philadelphia might be a popular parlay pick. That is reflected in their -156 Moneyline betting odds. Cleveland is the underdog at +132 and the Cavs are regarded as least likely to win.
There is a spread of 3.5 and total points has a line of 235.5. A Total wager is always available and can often provide value selections. There’s the chance to back Under 235.5 at -110.
The best betting sites offer hundreds of game lines and team props when it comes to most basketball contests. Make sure you look through all the available options before deciding which bet to place.
Betting Lines & Odds
Moneyline
Point Spread
Total Points
Donovan Mitchell Favorite to Get Most Points
Donovan Mitchell is favorite when it comes to hitting the most buckets. You can get -118 that he goes Over 25.5 points or the same odds when it comes to Under.
Player Points
Donovan Mitchell (Cavaliers)
Tyrese Maxey (76ers)
Joel Embiid (76ers)
Jaylen Brown (76ers)
Player Assists
LeBron James (76ers)
James Harden (Cavaliers)
Tyrese Maxey (76ers)
Donovan Mitchell (Cavaliers)
Player Rebounds
Joel Embiid (76ers)
Evan Mobley (Cavaliers)
Jarrett Allen (Cavaliers)
LeBron James (76ers)
Live market odds and lines updated regularly. All odds subject to change. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Xfinity Mobile Arena
Sixers Have Collected Five Wins From Last Ten at Home
The Sixers have gone 5-5 across their last 10 home games, averaging 111.00 points scored and 114.00 points allowed.
The Cavs have gone 2-8 across their last 10 road games, posting 104.20 points per contest while yielding 110.40.
In their most recent matchup at Xfinity Mobile Arena, the Cavs got the better of the Sixers 117-115. From the past 10 head-to-heads at Xfinity Mobile Arena, the Sixers have won six while the Cavs have taken four.
Philadelphia 76ers Home Stats
5-5
225.00
111.00
114.00
2
8
Cleveland Cavaliers Away Stats
2-8
214.60
104.20
110.40
0
10
W-L = Wins-Losses
P = Avg. Points
PF = Avg. Points For
PA = Avg. Points Against
O235.5 = Games Over 235.5 Points
U235.5 = Games Under 235.5 Points
Team Stats
Latest regular season and playoff games stats.
Cleveland Cavaliers Stats
Philadelphia 76ers Stats
4 wins and 6 defeats in the last 10 games
2 wins and 8 defeats in the last 10 games on the road
4 wins and 6 defeats in the last 10 games
5 wins and 5 defeats in the last 10 home games
+3.5 Betting Line: Have covered the spread in 4 of the last 10 games
+3.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road
-3.5 Betting Line: Have covered the spread in 4 of the last 10 games
-3.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games
Game Totals: An average of 217.50 pts in the previous 10 games
Game Totals on the Road: An average of 214.60 pts in the previous 10 games on the road
Over 235.5: Has not been covered in any of the previous 10 games
Over 235.5 on the Road: Has not been covered in any of the previous 10 games on the road
Team Totals: Have scored an average of 105.90 pts and allowed 111.60 pts in the last 10 games
Team Totals on the Road: Have scored an average of 104.20 pts and allowed 110.40 pts in the last 10 games on the road
Game Totals: An average of 216.10 pts in the previous 10 games
Game Totals at Home: An average of 225.00 pts in the previous 10 home games
Over 235.5: Covered in 1 of the previous 10 games
Over 235.5 at Home: Covered in 2 of the previous 10 home games
Team Totals: Have scored an average of 103.80 pts and allowed 112.30 pts in the last 10 games
Team Totals at Home: Have scored an average of 111.00 pts and allowed 114.00 pts in the last 10 home games
Last 10 Games
2-Pointers Made: 24.30 (56%)
3-Pointers Made: 11.80 (32%)
Free Throws Made: 21.90 (73.74%)
Rebounds: Total 38.3, Offensive 10.80, Defensive 27.50
Assists: 21.70
Blocks: 5.30
Steals: 7.70
Turnovers : 16.00
Personal Fouls: 19.60
Last 10 Games on the Road
2-Pointers Made: 25.00 (53%)
3-Pointers Made: 11.30 (30%)
Free Throws Made: 20.30 (74.91%)
Rebounds: Total 44.1, Offensive 13.10, Defensive 31.00
Assists: 22.30
Blocks: 5.60
Steals: 7.30
Turnovers : 16.30
Personal Fouls: 21.10
Last 10 Games
2-Pointers Made: 25.80 (53%)
3-Pointers Made: 11.00 (32%)
Free Throws Made: 19.20 (80.67%)
Rebounds: Total 38.1, Offensive 7.60, Defensive 30.50
Assists: 22.40
Blocks: 4.80
Steals: 5.80
Turnovers : 11.40
Personal Fouls: 21.30
Last 10 Home Games
2-Pointers Made: 29.10 (56%)
3-Pointers Made: 11.60 (34%)
Free Throws Made: 18.00 (80.36%)
Rebounds: Total 39.4, Offensive 8.90, Defensive 30.50
Assists: 23.50
Blocks: 6.20
Steals: 7.60
Turnovers : 11.00
Personal Fouls: 20.70
Expert Analysis by Elijah Jackson
Senior NBA Analyst
About the Analyst
Elijah Jackson is a Senior NBA Analyst and Head of the Basketball Editorial Betting Panel with 10+ years of experience, specialising in roster evaluation and efficiency-based analysis to uncover value across NBA markets.
NBA Predictions Methodology
Our NBA analysis focuses on efficiency, pace and player performance ratings. We combine player availability, schedule context, lineup data and market movement with metrics such as Offensive Rating (ORTG), Defensive Rating (DRTG), Net Rating and Effective Field Goal Percentage (eFG%) to assess overall team strength, fatigue analysis and find value in high-paced games.
Full Prediction Methodology & Data Sources
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Transparency & Safety
This preview was last updated on Oct 21, 22:40 to reflect the latest team news, injury reports, starting lineups, player rotations, rest and travel factors, key performance metrics and odds movement.
All analysis is produced by professional analysts, supported by proprietary internal models, advanced performance metrics and reviewed by our Basketball Editorial Betting Panel for accuracy and consistency.
Historical performance for our game predictions is tracked and updated regularly for transparency.
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