The Philadelphia 76ers (5-2) and the Cleveland Cavaliers (4-3) meet Wednesday at Rocket Arena in Cleveland, Ohio. Tip-off is scheduled for 7 p.m. ET. Let’s analyze BetMGM Sportsbook’s NBA odds around the 76ers vs. Cavaliers odds and make our expert NBA picks and predictions for the best bets.

2024-25 season series: Cavaliers won 2-1

The 76ers won the most recent meeting in Philadelphia 132-129 as a 9-point underdog at home on Jan. 24 as the Over (230.5) cashed. The 76ers are 5-1 against the spread (ATS) in the past 6 meetings in the series, and the Over has cashed in 4 straight in the series, while the total has gone high in 8 of the past 9 meetings.

Philadelphia suffered a 113-111 loss at the Chicago Bulls last time out on Tuesday as a 2-point underdog as the Under (240) cashed, and now it plays on no rest. G Tyrese Maxey was on fire with 39 points, including 6 triples, while posting 5 assists, 5 rebounds and 3 blocks in 39 minutes.

In its only previous game on no rest, the Sixers won 139-134 in OT in Washington as a 4.5-point favorite as the Over (239.5) cashed. Philly is 4-0-1 ATS in the past 5 games, and 5-1-1 ATS this season. The Under is 2-1 in the past 3 games after the total went high in the first 4 outings.

Cleveland posted a 117-109 victory Sunday ovee the Atlanta Hawks as a 6.5-point home favorite as the Under (231) cashed. G Donovan Mitchell went for 37 points with 8 made 3-pointers, 5 assists, 2 steals and a block. F De’Andre Hunter was second-best with 19 points, while G Jaylon Tyson went for 18 points and 5 successful makes from behind the arc.

The Cavaliers picked up the cover against the Hawks, just the second ATS win in 7 tries this season. The Under has cashed in 5 straight outings.

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76ers at Cavaliers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:23 a.m. ET.

Moneyline (ML): 76ers +333 (bet $100 to win $333) | Cavaliers -450 (bet $450 to win $100)Against the spread (ATS): 76ers +9.5 (-105) | Cavaliers -9.5 (-115)Over/Under (O/U): 235.5 (O: -110 | U: -110)76ers at Cavaliers injuries

76ers

(Not yet submitted — below was for Tuesday’s game)

F Dominick Barlow (elbow) questionableF Paul George (knee) questionable

Cavaliers

F Jarrett Allen (hamstring) questionableG Darius Garland (Achilles) questionableG Sam Merrill (hip) questionableF Max Strus (knee) out

For most recent updates: Official NBA injury report.

76ers at Cavaliers picks and predictionsPrediction

Cavaliers 116, 76ers 110

PASS.

Cleveland (-450) will cost you 4 1/2 times your potential return, and that’s way too much risk for not enough return.

Philadelphia enters with a better record than Cleveland, but it is also just 1-3 in the past 4 meetings since March 29 of last season.

BET 76ERS +9.5 (-105).

The Cavaliers have had a difficult time against the number, going just 2-5 ATS. The defense has been an issue, allowing 112 or more points in 5 of its 7 outings.

The Cavs should win, but look for the Sixers to keep it within single digits.

The UNDER 235.5 (-110) is a strong play, as this is a big number.

Cleveland has cashed the Under in 5 consecutive outings, and Philadelphia has hit the Over in 2 of the past 3 outings. While the Over cashed in all 3 meetings last season, and it is 8-1 in the past 9 in the series, both teams have been hitting low lately.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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